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Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones.

Abstract：

:We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic active zones, independent of their target cells. In myoblast city mutant embryos, myoblasts do not fuse but form fully differentiated mononucleate muscles, which make functional neuromuscular synapses with correctly localized presynaptic active zones. Myoblasts also fail to fuse but still attract appropriate innervation in mef2 mutant embryos. However, these myoblasts fail to differentiate into muscles and presynaptic active zones fail to localize at neuromuscular contacts. Thus, the process of synapse formation can be genetically separated from the process of target recognition, revealing that localization of presynaptic active zones requires mef2-dependent muscle differentiation.

journal_name

Neuron

journal_title

Neuron

authors

Prokop A,Landgraf M,Rushton E,Broadie K,Bate M

doi

10.1016/s0896-6273(00)80195-6

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

617-26

issue

4

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(00)80195-6

journal_volume

17

pub_type

杂志文章

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