Abstract:
:Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal and cardiac alpha 1 subunits, respectively. When compared with skeletal and cardiac alpha 1 isoforms, the rat brain protein is intermediate in size at the amino terminus and shorter at the carboxyl terminus. Multiple subtypes of this alpha 1 isoform cDNA were characterized. These are indicative of alternative splicing of a primary transcript and encode three variants between motif I and motif II and two within the S3 region of motif IV. Thus, multiple isoforms of this rat brain alpha 1 subunit are possible.
journal_name
Neuronjournal_title
Neuronauthors
Hui A,Ellinor PT,Krizanova O,Wang JJ,Diebold RJ,Schwartz Adoi
10.1016/0896-6273(91)90072-8subject
Has Abstractpub_date
1991-07-01 00:00:00pages
35-44issue
1eissn
0896-6273issn
1097-4199pii
0896-6273(91)90072-8journal_volume
7pub_type
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