Abstract：
:To achieve simultaneous measurement of multiple cellular events in molecularly defined groups of neurons in vivo, we designed a spectrometer-based fiber photometry system that allows for spectral unmixing of multiple fluorescence signals recorded from deep brain structures in behaving animals. Using green and red Ca2+ indicators differentially expressed in striatal direct- and indirect-pathway neurons, we were able to simultaneously monitor the neural activity in these two pathways in freely moving animals. We found that the activities were highly synchronized between the direct and indirect pathways within one hemisphere and were desynchronized between the two hemispheres. We further analyzed the relationship between the movement patterns and the magnitude of activation in direct- and indirect-pathway neurons and found that the striatal direct and indirect pathways coordinately control the dynamics and fate of movement. VIDEO ABSTRACT.
journal_name
Neuronjournal_title
Neuronauthors
Meng C,Zhou J,Papaneri A,Peddada T,Xu K,Cui Gdoi
10.1016/j.neuron.2018.04.012subject
Has Abstractpub_date
2018-05-16 00:00:00pages
707-717.e4issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30296-4journal_volume
98pub_type
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