Abstract：
:Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion of the voltage sensor. We interpret the results in light of the recent crystal structure of the mammalian potassium channel Kv1.2. We focus on the transmembrane movement of the voltage sensor as a key element to the detection of membrane potential and to the control of channel gating.
journal_name
Neuronjournal_title
Neuronauthors
Tombola F,Pathak MM,Isacoff EYdoi
10.1016/j.neuron.2005.11.024subject
Has Abstractpub_date
2005-12-08 00:00:00pages
719-25issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(05)01004-4journal_volume
48pub_type
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