Abstract：
:Neurodegenerative diseases have been intensively studied, but a comprehensive understanding of their pathogenesis remains elusive. An increasing body of evidence suggests that non-cell-autonomous processes play critical roles during the initiation and spatiotemporal progression or propagation of the dominant pathology. Here, we review findings highlighting the importance of pathological cell-cell communication in neurodegenerative disease. We focus primarily on the accumulating evidence suggesting dysfunctional crosstalk between neurons and astroglia, neurons and innate immune system cells, as well as cellular processes leading to transmission of pathogenic proteins between cells. Insights into the complex intercellular perturbations underlying neurodegeneration will enhance our efforts to develop effective therapeutic approaches for preventing or reversing symptomatic progression in this devastating class of human diseases.
journal_name
Neuronjournal_title
Neuronauthors
Garden GA,La Spada ARdoi
10.1016/j.neuron.2012.02.017subject
Has Abstractpub_date
2012-03-08 00:00:00pages
886-901issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00179-1journal_volume
73pub_type
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