When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids.


:In this issue of Neuron, Viader et al. (2013) report on the production of toxic lipids by Schwann cells deficient in mitochondrial respiration, which are capable of destroying neighboring axons. This may have implications for understanding the neurobiology and treatment of mitochondrial neuropathies.






Di Paolo G,Przedborski S




Has Abstract


2013-03-06 00:00:00
















  • Learning without performance in PKC-deficient Drosophila.

    abstract::The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...


    pub_type: 杂志文章


    authors: Kane NS,Robichon A,Dickinson JA,Greenspan RJ

    更新日期:1997-02-01 00:00:00

  • Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.

    abstract::Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse chan...


    pub_type: 杂志文章


    authors: Wang GX,Smith SJ,Mourrain P

    更新日期:2014-12-17 00:00:00

  • A new ion channel blooms at the synapse.

    abstract::A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...


    pub_type: 杂志文章


    authors: Kuo SP,Trussell LO

    更新日期:2009-09-10 00:00:00

  • Seeing is believing: GFP transgenics illuminate synapse elimination.

    abstract::Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...


    pub_type: 评论,杂志文章


    authors: Thompson WJ

    更新日期:2001-08-16 00:00:00

  • A Meta-Analysis Suggests Different Neural Correlates for Implicit and Explicit Learning.

    abstract::A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...


    pub_type: 杂志文章,meta分析


    authors: Loonis RF,Brincat SL,Antzoulatos EG,Miller EK

    更新日期:2017-10-11 00:00:00

  • Cellular basis for the response to second-order motion cues in Y retinal ganglion cells.

    abstract::We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...


    pub_type: 杂志文章


    authors: Demb JB,Zaghloul K,Sterling P

    更新日期:2001-11-20 00:00:00

  • A pair of interneurons influences the choice between feeding and locomotion in Drosophila.

    abstract::The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...


    pub_type: 杂志文章


    authors: Mann K,Gordon MD,Scott K

    更新日期:2013-08-21 00:00:00

  • Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli.

    abstract::Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...


    pub_type: 杂志文章


    authors: Cho JR,Treweek JB,Robinson JE,Xiao C,Bremner LR,Greenbaum A,Gradinaru V

    更新日期:2017-06-21 00:00:00

  • CNS glial cells support in vitro survival, division, and differentiation of dissociated olfactory neuronal progenitor cells.

    abstract::Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...


    pub_type: 杂志文章


    authors: Pixley SK

    更新日期:1992-06-01 00:00:00

  • Signal Amplification in Drosophila Olfactory Receptor Neurons.

    abstract::Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship b...


    pub_type: 评论,杂志文章


    authors: Kim BS,Suh GSB

    更新日期:2019-12-04 00:00:00

  • Efficient discrimination of temporal patterns by motion-sensitive neurons in primate visual cortex.

    abstract::Although motion-sensitive neurons in macaque middle temporal (MT) area are conventionally characterized using stimuli whose velocity remains constant for 1-3 s, many ecologically relevant stimuli change on a shorter time scale (30-300 ms). We compared neuronal responses to conventional (constant-velocity) and time-var...


    pub_type: 杂志文章


    authors: Buracas GT,Zador AM,DeWeese MR,Albright TD

    更新日期:1998-05-01 00:00:00

  • Two-back makes step forward in brain imaging genomics.

    abstract::The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...


    pub_type: 评论,杂志文章


    authors: McIntosh A,Deary I,Porteous DJ

    更新日期:2014-03-05 00:00:00

  • Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate.

    abstract::L-Glutamate is regarded as the major excitatory neurotransmitter in the mammalian CNS. However, whether the released transmitter originates from a cytosolic pool or is discharged from synaptic vesicles by exocytosis (vesicle hypothesis) remains controversial. A problem with the general acceptance of the vesicle hypoth...


    pub_type: 杂志文章


    authors: Burger PM,Mehl E,Cameron PL,Maycox PR,Baumert M,Lottspeich F,De Camilli P,Jahn R

    更新日期:1989-12-01 00:00:00

  • Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus.

    abstract::Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We h...


    pub_type: 杂志文章


    authors: Melnick I,Pronchuk N,Cowley MA,Grove KL,Colmers WF

    更新日期:2007-12-20 00:00:00

  • Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.

    abstract::Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...


    pub_type: 杂志文章


    authors: Zhao Y,Sivaji S,Chiang MC,Ali H,Zukowski M,Ali S,Kennedy B,Sklyar A,Cheng A,Guo Z,Reed AK,Kodali R,Borowski J,Frost G,Beukema P,Wills ZP

    更新日期:2017-10-11 00:00:00

  • Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data.

    abstract::We present a modular approach for analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and denoise and deconvolve the spiking activity from the slow dynamics of the calcium indicator. Our approach ...


    pub_type: 杂志文章


    authors: Pnevmatikakis EA,Soudry D,Gao Y,Machado TA,Merel J,Pfau D,Reardon T,Mu Y,Lacefield C,Yang W,Ahrens M,Bruno R,Jessell TM,Peterka DS,Yuste R,Paninski L

    更新日期:2016-01-20 00:00:00

  • Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.

    abstract::During development of the peripheral nervous system (PNS), Schwann-cell-secreted gliomedin induces the clustering of Na+ channels at the edges of each myelin segment to form nodes of Ranvier. Here we show that bone morphogenetic protein-1 (BMP1)/Tolloid (TLD)-like proteinases confine Na+ channel clustering to these si...


    pub_type: 杂志文章


    authors: Eshed-Eisenbach Y,Devaux J,Vainshtein A,Golani O,Lee SJ,Feinberg K,Sukhanov N,Greenspan DS,Susuki K,Rasband MN,Peles E

    更新日期:2020-06-03 00:00:00

  • Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila.

    abstract::We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...


    pub_type: 杂志文章


    authors: Kohatsu S,Koganezawa M,Yamamoto D

    更新日期:2011-02-10 00:00:00

  • Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness.

    abstract::The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...


    pub_type: 杂志文章,评审


    authors: Buckholtz JW,Meyer-Lindenberg A

    更新日期:2012-06-21 00:00:00

  • Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins.

    abstract::Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery. Recent studie...


    pub_type: 杂志文章,评审


    authors: Maher MP,Matta JA,Gu S,Seierstad M,Bredt DS

    更新日期:2017-12-06 00:00:00

  • Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance.

    abstract::Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-...


    pub_type: 杂志文章


    authors: Tojima T,Itofusa R,Kamiguchi H

    更新日期:2010-05-13 00:00:00

  • Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.

    abstract::Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels...


    pub_type: 杂志文章


    authors: Yeh SY,Huang WH,Wang W,Ward CS,Chao ES,Wu Z,Tang B,Tang J,Sun JJ,Esther van der Heijden M,Gray PA,Xue M,Ray RS,Ren D,Zoghbi HY

    更新日期:2017-04-19 00:00:00

  • cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor.

    abstract::Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...


    pub_type: 杂志文章


    authors: Schoepfer R,Whiting P,Esch F,Blacher R,Shimasaki S,Lindstrom J

    更新日期:1988-05-01 00:00:00

  • Nitric oxide production by brain stem neurons is required for normal performance of eye movements in alert animals.

    abstract::Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...


    pub_type: 杂志文章


    authors: Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

    更新日期:1996-10-01 00:00:00

  • A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses.

    abstract::Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...


    pub_type: 杂志文章


    authors: Zhou Z,Liu X,Chen S,Zhang Z,Liu Y,Montardy Q,Tang Y,Wei P,Liu N,Li L,Song R,Lai J,He X,Chen C,Bi G,Feng G,Xu F,Wang L

    更新日期:2019-08-07 00:00:00

  • Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.

    abstract::Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...


    pub_type: 杂志文章


    authors: Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

    更新日期:2010-01-14 00:00:00

  • Time finds its place in the hippocampus.

    abstract::In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...


    pub_type: 评论,杂志文章


    authors: Rowland DC,Moser MB

    更新日期:2013-06-19 00:00:00

  • Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding.

    abstract::GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...


    pub_type: 杂志文章


    authors: Coyle JE,Qamar S,Rajashankar KR,Nikolov DB

    更新日期:2002-01-03 00:00:00

  • Von Economo neurons in the anterior insula of the macaque monkey.

    abstract::The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...


    pub_type: 杂志文章


    authors: Evrard HC,Forro T,Logothetis NK

    更新日期:2012-05-10 00:00:00

  • Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease.

    abstract::Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and other physiological responses. They are encoded by ten genes, which generate three voltage-gated calcium channel subfamilies: CaV1; CaV2;...


    pub_type: 杂志文章,评审


    authors: Nanou E,Catterall WA

    更新日期:2018-05-02 00:00:00