Neurons in area V4 of the macaque translate attended visual features into behaviorally relevant categories.

Abstract:

:Neural processing at most stages of the primate visual system is modulated by selective attention, such that behaviorally relevant information is emphasized at the expenses of irrelevant, potentially distracting information. The form of attention best understood at the cellular level is when stimuli at a given location in the visual field must be selected (space-based attention). In contrast, fewer single-unit recording studies have so far explored the cellular mechanisms of attention operating on individual stimulus features, specifically when one feature (e.g., color) of an object must guide behavioral responses while a second feature (e.g., shape) of the same object is potentially interfering and therefore must be ignored. Here we show that activity of neurons in macaque area V4 can underlie the selection of elemental object features and their "translation" into a categorical format that can directly contribute to the control of the animal's behavior.

journal_name

Neuron

journal_title

Neuron

authors

Mirabella G,Bertini G,Samengo I,Kilavik BE,Frilli D,Della Libera C,Chelazzi L

doi

10.1016/j.neuron.2007.04.007

subject

Has Abstract

pub_date

2007-04-19 00:00:00

pages

303-18

issue

2

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(07)00257-7

journal_volume

54

pub_type

杂志文章

相关文献

NEURON文献大全
  • MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion.

    abstract::The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(02)00672-4

    authors: Huang X,Cheng HJ,Tessier-Lavigne M,Jin Y

    更新日期:2002-05-16 00:00:00

  • A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses.

    abstract::Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.05.027

    authors: Zhou Z,Liu X,Chen S,Zhang Z,Liu Y,Montardy Q,Tang Y,Wei P,Liu N,Li L,Song R,Lai J,He X,Chen C,Bi G,Feng G,Xu F,Wang L

    更新日期:2019-08-07 00:00:00

  • Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor epsilon subunit.

    abstract::We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80996-4

    authors: Milone M,Wang HL,Ohno K,Prince R,Fukudome T,Shen XM,Brengman JM,Griggs RC,Sine SM,Engel AG

    更新日期:1998-03-01 00:00:00

  • The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration.

    abstract::Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.10.004

    authors: Isaacman-Beck J,Schneider V,Franzini-Armstrong C,Granato M

    更新日期:2015-11-18 00:00:00

  • Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM.

    abstract::Among the diverse interneuron subtypes in the neocortex, chandelier cells (ChCs) are the only population that selectively innervate pyramidal neurons (PyNs) at their axon initial segment (AIS), the site of action potential initiation, allowing them to exert powerful control over PyN output. Yet, mechanisms underlying ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.02.009

    authors: Tai Y,Gallo NB,Wang M,Yu JR,Van Aelst L

    更新日期:2019-04-17 00:00:00

  • Pathway interactions and synaptic plasticity in the dendritic tuft regions of CA1 pyramidal neurons.

    abstract::Input comparison is thought to occur in many neuronal circuits, including the hippocampus, where functionally important interactions between the Schaffer collateral and perforant pathways have been hypothesized. We investigated this idea using multisite, whole-cell recordings and Ca2+ imaging and found that properly t...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2009.03.007

    authors: Takahashi H,Magee JC

    更新日期:2009-04-16 00:00:00

  • Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons.

    abstract::Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.03.001

    authors: Cohen SM,Ma H,Kuchibhotla KV,Watson BO,Buzsáki G,Froemke RC,Tsien RW

    更新日期:2016-04-20 00:00:00

  • EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

    abstract::EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.02.003

    authors: Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

    更新日期:2012-02-23 00:00:00

  • Parkin and the molecular pathways of Parkinson's disease.

    abstract::Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(01)00439-1

    authors: Giasson BI,Lee VM

    更新日期:2001-09-27 00:00:00

  • Neurons, networks, and motor behavior.

    abstract::The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(00)80043-4

    authors: Katz PS

    更新日期:1996-02-01 00:00:00

  • Neural regulation of hematopoiesis, inflammation, and cancer.

    abstract::Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2015.01.026

    authors: Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

    更新日期:2015-04-22 00:00:00

  • The relationship of anatomical and functional connectivity to resting-state connectivity in primate somatosensory cortex.

    abstract::Studies of resting-state activity in the brain have provoked critical questions about the brain's functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.04.023

    authors: Wang Z,Chen LM,Négyessy L,Friedman RM,Mishra A,Gore JC,Roe AW

    更新日期:2013-06-19 00:00:00

  • Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior.

    abstract::Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it changes the state of neuronal networks throughout the brain and modifies their response to internal and external inputs: the classical rol...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2012.08.036

    authors: Picciotto MR,Higley MJ,Mineur YS

    更新日期:2012-10-04 00:00:00

  • Shunting inhibition modulates neuronal gain during synaptic excitation.

    abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00200-9

    authors: Mitchell SJ,Silver RA

    更新日期:2003-05-08 00:00:00

  • Time finds its place in the hippocampus.

    abstract::In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2013.05.039

    authors: Rowland DC,Moser MB

    更新日期:2013-06-19 00:00:00

  • Network Dynamics Mediate Circadian Clock Plasticity.

    abstract::A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can change circadian period length through a mechanism requiring de novo DNA methylation. We show here that this mechanism is mediated not via cell-autonomous clock p...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.12.022

    authors: Azzi A,Evans JA,Leise T,Myung J,Takumi T,Davidson AJ,Brown SA

    更新日期:2017-01-18 00:00:00

  • The role of apolipoprotein E in Alzheimer's disease.

    abstract::The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2009.06.026

    authors: Kim J,Basak JM,Holtzman DM

    更新日期:2009-08-13 00:00:00

  • Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

    abstract::Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.05.032

    authors: Held RG,Liu C,Ma K,Ramsey AM,Tarr TB,De Nola G,Wang SSH,Wang J,van den Maagdenberg AMJM,Schneider T,Sun J,Blanpied TA,Kaeser PS

    更新日期:2020-08-19 00:00:00

  • Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model.

    abstract::How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.04.002

    authors: O'Leary T,Williams AH,Franci A,Marder E

    更新日期:2014-05-21 00:00:00

  • Tracking Down Mutations Cell by Cell.

    abstract::Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2016.02.042

    authors: Kosik KS

    更新日期:2016-03-16 00:00:00

  • A dual operator view of habitual behavior reflecting cortical and striatal dynamics.

    abstract::Habits are notoriously difficult to break and, if broken, are usually replaced by new routines. To examine the neural basis of these characteristics, we recorded spike activity in cortical and striatal habit sites as rats learned maze tasks. Overtraining induced a shift from purposeful to habitual behavior. This shift...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.05.038

    authors: Smith KS,Graybiel AM

    更新日期:2013-07-24 00:00:00

  • Nociceptors--noxious stimulus detectors.

    abstract::In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2007.07.016

    authors: Woolf CJ,Ma Q

    更新日期:2007-08-02 00:00:00

  • Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.

    abstract::Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.07.037

    authors: Maruyama M,Shimada H,Suhara T,Shinotoh H,Ji B,Maeda J,Zhang MR,Trojanowski JQ,Lee VM,Ono M,Masamoto K,Takano H,Sahara N,Iwata N,Okamura N,Furumoto S,Kudo Y,Chang Q,Saido TC,Takashima A,Lewis J,Jang MK,Aoki I,

    更新日期:2013-09-18 00:00:00

  • The Mechanisms and Functions of Synaptic Facilitation.

    abstract::The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2017.02.047

    authors: Jackman SL,Regehr WG

    更新日期:2017-05-03 00:00:00

  • Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.

    abstract::Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.12.015

    authors: Bai B,Wang X,Li Y,Chen PC,Yu K,Dey KK,Yarbro JM,Han X,Lutz BM,Rao S,Jiao Y,Sifford JM,Han J,Wang M,Tan H,Shaw TI,Cho JH,Zhou S,Wang H,Niu M,Mancieri A,Messler KA,Sun X,Wu Z,Pagala V,High AA,Bi W,Zhan

    更新日期:2020-03-18 00:00:00

  • Cortical Circuit Dynamics Are Homeostatically Tuned to Criticality In Vivo.

    abstract::Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives rise to balanced network dynamics is unknown. Here, we continuously monitored the statistics of network spiking in visual cortical circuits in freely behaving rats for 9 days. Under control conditions in light and dark, networks...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.08.031

    authors: Ma Z,Turrigiano GG,Wessel R,Hengen KB

    更新日期:2019-11-20 00:00:00

  • Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.

    abstract::Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.08.023

    authors: Dulcis D,Lippi G,Stark CJ,Do LH,Berg DK,Spitzer NC

    更新日期:2017-09-13 00:00:00

  • Competing global representations fail to initiate binocular rivalry.

    abstract::A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.08.039

    authors: Carlson TA,He S

    更新日期:2004-09-16 00:00:00

  • Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF.

    abstract::mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(91)90265-2

    authors: Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RA

    更新日期:1991-08-01 00:00:00

  • Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.

    abstract::To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase i...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.12.029

    authors: Lim ET,Raychaudhuri S,Sanders SJ,Stevens C,Sabo A,MacArthur DG,Neale BM,Kirby A,Ruderfer DM,Fromer M,Lek M,Liu L,Flannick J,Ripke S,Nagaswamy U,Muzny D,Reid JG,Hawes A,Newsham I,Wu Y,Lewis L,Dinh H,Gross S,W

    更新日期:2013-01-23 00:00:00