Abstract：
:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evidence suggests that the differential effects of apoE isoforms on Abeta aggregation and clearance play the major role in AD pathogenesis. Other potential mechanisms, such as the differential modulation of neurotoxicity and tau phosphorylation by apoE isoforms as well as its role in synaptic plasticity and neuroinflammation, have not been ruled out. Inconsistent results among studies have made it difficult to define whether the APOE epsilon4 allele represents a gain of toxic function, a loss of neuroprotective function, or both. Therapeutic strategies based on apoE propose to reduce the toxic effects of apoE4 or to restore the physiological, protective functions of apoE.
journal_name
Neuronjournal_title
Neuronauthors
Kim J,Basak JM,Holtzman DMdoi
10.1016/j.neuron.2009.06.026subject
Has Abstractpub_date
2009-08-13 00:00:00pages
287-303issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00549-2journal_volume
63pub_type
杂志文章,评审相关文献
NEURON文献大全abstract：:Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it changes the state of neuronal networks throughout the brain and modifies their response to internal and external inputs: the classical rol...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2012.08.036
更新日期：2012-10-04 00:00:00
abstract：:The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion when navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons called grid cells that form part of the spatial navigation syst...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.023
更新日期：2017-02-08 00:00:00
abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.11.027
更新日期：2006-01-05 00:00:00
abstract：:Phorbol esters and purified protein kinase C (PKC) have been shown to down-modulate the voltage-dependent Na+ channels expressed in Xenopus oocytes injected with chick brain RNA. We used the two-electrode voltage-clamp technique to demonstrate that a Na+ channel expressed in oocytes injected with RNA coding for the al...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90131-i
更新日期：1991-01-01 00:00:00
abstract：:Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing a...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(02)00967-4
更新日期：2002-10-10 00:00:00
abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.021
更新日期：2016-12-07 00:00:00
abstract：:Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.09.050
更新日期：2015-11-18 00:00:00
abstract：:Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter mi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.03.026
更新日期：2009-05-14 00:00:00
abstract：:Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)01026-7
更新日期：2002-11-14 00:00:00
abstract：:The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.12.016
更新日期：2013-02-20 00:00:00
abstract：:A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(02)00943-1
更新日期：2002-09-26 00:00:00
abstract：:Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (alpha) rhythm. However, how the alpha rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the latera...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.08.012
更新日期：2009-09-10 00:00:00
abstract：:Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81174-5
更新日期：2000-05-01 00:00:00
abstract：:Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90114-s
更新日期：1992-01-01 00:00:00
abstract：:S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.05.005
更新日期：2013-05-22 00:00:00
abstract：:Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00092-1
更新日期：2000-10-01 00:00:00
abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.043
更新日期：2015-12-02 00:00:00
abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.01.003
更新日期：2020-04-08 00:00:00
abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.09.052
更新日期：2015-10-21 00:00:00
abstract：:T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.036
更新日期：2014-09-03 00:00:00
abstract：:Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.040
更新日期：2019-04-17 00:00:00
abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.12.013
更新日期：2009-01-29 00:00:00
abstract：:Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.041
更新日期：2017-10-11 00:00:00
abstract：:The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...
journal_title：Neuron
pub_type： 历史文章,杂志文章
doi：10.1016/j.neuron.2016.05.014
更新日期：2016-06-15 00:00:00
abstract：:In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.12.034
更新日期：2019-01-16 00:00:00
abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.03.029
更新日期：2015-04-08 00:00:00
abstract：:Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.10.040
更新日期：2014-12-03 00:00:00
abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.05.003
更新日期：2015-05-20 00:00:00
abstract：:Neuronal circuit function is governed by precise patterns of connectivity between specialized groups of neurons. The diversity of GABAergic interneurons is a hallmark of cortical circuits, yet little is known about their targeting to individual postsynaptic dendrites. We examined synaptic connectivity between molecula...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.01.029
更新日期：2016-03-02 00:00:00
abstract：:To investigate the structural determinants underlying transport by the glutamate transporter EAAT1, we mutated each of 24 highly conserved residues (P392 to Q415) to cysteine. A majority of these substituted cysteines react with the sulfhydryl-modifying reagent MTSEA, suggesting that they reside in an aqueous environm...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80666-2
更新日期：1998-12-01 00:00:00
