Abstract：
:S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways, akin to phosphorylation. However, with aging or environmental toxins that generate excessive NO, aberrant S-nitrosylation reactions can occur and affect protein misfolding, mitochondrial fragmentation, synaptic function, apoptosis or autophagy. Here, we discuss how aberrantly S-nitrosylated proteins (SNO-proteins) play a crucial role in the pathogenesis of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. Insight into the pathophysiological role of aberrant S-nitrosylation pathways will enhance our understanding of molecular mechanisms leading to neurodegenerative diseases and point to potential therapeutic interventions.
journal_name
Neuronjournal_title
Neuronauthors
Nakamura T,Tu S,Akhtar MW,Sunico CR,Okamoto S,Lipton SAdoi
10.1016/j.neuron.2013.05.005subject
Has Abstractpub_date
2013-05-22 00:00:00pages
596-614issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00398-Xjournal_volume
78pub_type
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