Abstract:
:Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-filled lumen of the semicircular canals is severely reduced. EphB2 is expressed in the endolymph-producing dark cells in the inner ear epithelium, and these cells show ultrastructural defects in the mutants. A molecular link to fluid regulation is provided by demonstrating that PDZ domain-containing proteins that bind the C termini of EphB2 and B-ephrins can also recognize the cytoplasmic tails of anion exchangers and aquaporins. This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water.
journal_name
Neuronjournal_title
Neuronauthors
Cowan CA,Yokoyama N,Bianchi LM,Henkemeyer M,Fritzsch Bdoi
10.1016/s0896-6273(00)81174-5subject
Has Abstractpub_date
2000-05-01 00:00:00pages
417-30issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)81174-5journal_volume
26pub_type
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