Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

abstract：:MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...

journal_title：Neuron

authors： Edbauer D,Neilson JR,Foster KA,Wang CF,Seeburg DP,Batterton MN,Tada T,Dolan BM,Sharp PA,Sheng M

更新日期：2010-02-11 00:00:00

abstract：:Pheromonal activation of the vomeronasal organ (VNO) elicits genetically preprogrammed behaviors and physiological changes in mammals. We have identified a novel gene family encoding over one hundred VNO specific receptors, the V3Rs. V3R sequences are highly similar to each other and appear distantly related to the pu...

journal_title：Neuron

authors： Pantages E,Dulac C

更新日期：2000-12-01 00:00:00

abstract：:TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chron...

journal_title：Neuron

authors： Fine M,Li X

更新日期：2021-01-20 00:00:00

abstract：:An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal...

journal_title：Neuron

authors： Feany MB,Pallanck LJ

更新日期：2003-04-10 00:00:00

abstract：:To define the cis-acting DNA elements required for rhodopsin expression, we generated lines of transgenic mice carrying sequences upstream of the bovine rhodopsin gene fused to the E. coli beta-galactosidase gene (lacZ). Upstream sequences extending from -2174 to +70 bp, from -734 to +70 bp, and from -222 to +70 bp di...

journal_title：Neuron

authors： Zack DJ,Bennett J,Wang Y,Davenport C,Klaunberg B,Gearhart J,Nathans J

更新日期：1991-02-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...

journal_title：Neuron

authors： Brockie PJ,Mellem JE,Hills T,Madsen DM,Maricq AV

更新日期：2001-08-30 00:00:00

abstract：:Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive. Monoclonal antibodies in development target both soluble and insoluble Aβ peptide. We h...

journal_title：Neuron

authors： Demattos RB,Lu J,Tang Y,Racke MM,Delong CA,Tzaferis JA,Hole JT,Forster BM,McDonnell PC,Liu F,Kinley RD,Jordan WH,Hutton ML

更新日期：2012-12-06 00:00:00

abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...

journal_title：Neuron

authors： Jacoby J,Nath A,Jessen ZF,Schwartz GW

更新日期：2018-12-05 00:00:00

abstract：:Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...

journal_title：Neuron

authors： Shalom S,Zaidel A

更新日期：2018-02-07 00:00:00

abstract：:Natural vision often involves recognizing objects from partial information. Recognition of objects from parts presents a significant challenge for theories of vision because it requires spatial integration and extrapolation from prior knowledge. Here we recorded intracranial field potentials of 113 visually selective ...

journal_title：Neuron

authors： Tang H,Buia C,Madhavan R,Crone NE,Madsen JR,Anderson WS,Kreiman G

更新日期：2014-08-06 00:00:00

abstract：:The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...

journal_title：Neuron

authors： Zerbi V,Floriou-Servou A,Markicevic M,Vermeiren Y,Sturman O,Privitera M,von Ziegler L,Ferrari KD,Weber B,De Deyn PP,Wenderoth N,Bohacek J

更新日期：2019-08-21 00:00:00

abstract：:Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively ...

journal_title：Neuron

authors： Heck A,Fastenrath M,Ackermann S,Auschra B,Bickel H,Coynel D,Gschwind L,Jessen F,Kaduszkiewicz H,Maier W,Milnik A,Pentzek M,Riedel-Heller SG,Ripke S,Spalek K,Sullivan P,Vogler C,Wagner M,Weyerer S,Wolfsgruber S,de

更新日期：2014-03-05 00:00:00

abstract：:Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negat...

journal_title：Neuron

authors： Luo L,Wen Q,Ren J,Hendricks M,Gershow M,Qin Y,Greenwood J,Soucy ER,Klein M,Smith-Parker HK,Calvo AC,Colón-Ramos DA,Samuel AD,Zhang Y

更新日期：2014-06-04 00:00:00

abstract：:Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenul...

journal_title：Neuron

authors： Huang L,Xi Y,Peng Y,Yang Y,Huang X,Fu Y,Tao Q,Xiao J,Yuan T,An K,Zhao H,Pu M,Xu F,Xue T,Luo M,So KF,Ren C

更新日期：2019-04-03 00:00:00

abstract：:Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular...

journal_title：Neuron

authors： Bush AI

更新日期：2010-01-28 00:00:00

abstract：:Na+ channels are present at high density in squid giant axon but are absent from its somata in the giant fiber lobe (GFL) of the stellate ganglion. GFL cells dispersed in vitro maintain growing axons and develop a Na+ channel distribution similar to that in vivo. Tunicamycin, a glycosylation inhibitor, selectively dis...

journal_title：Neuron

authors： Gilly WF,Lucero MT,Horrigan FT

更新日期：1990-11-01 00:00:00

abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...

journal_title：Neuron

authors： Flucher BE,Morton ME,Froehner SC,Daniels MP

更新日期：1990-09-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...

journal_title：Neuron

authors： Ninan I,Arancio O

更新日期：2004-04-08 00:00:00

abstract：:Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in...

journal_title：Neuron

authors： Jack CR Jr,Holtzman DM

更新日期：2013-12-18 00:00:00

abstract：:This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...

journal_title：Neuron

authors： Petersen RS,Panzeri S,Diamond ME

更新日期：2001-11-08 00:00:00

abstract：:Using a transgenic mouse line in which GFP is expressed in a single population of retinal ganglion cells (RGCs), Huberman and colleagues report in this issue of Neuron that the axon terminals of RGCs exhibit an orderly pattern of distribution in the higher visual centers. This pattern undergoes a developmental refinem...

journal_title：Neuron

authors： He S

更新日期：2008-08-14 00:00:00

abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...

journal_title：Neuron

authors： Brunwasser SJ,Hengen KB

更新日期：2020-02-19 00:00:00

abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...

journal_title：Neuron

authors： Divakaruni SS,Van Dyke AM,Chandra R,LeGates TA,Contreras M,Dharmasri PA,Higgs HN,Lobo MK,Thompson SM,Blanpied TA

更新日期：2018-11-21 00:00:00

abstract：:Our perception of fine visual detail relies on small receptive fields at early stages of visual processing. However, small receptive fields tend to confound the orientation and velocity of moving edges, leading to ambiguous or inaccurate motion measurements (the aperture problem). Thus, it is often assumed that neuron...

journal_title：Neuron

authors： Pack CC,Livingstone MS,Duffy KR,Born RT

更新日期：2003-08-14 00:00:00

abstract：:A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...

journal_title：Neuron

authors： Kawano T,Po MD,Gao S,Leung G,Ryu WS,Zhen M

更新日期：2011-11-17 00:00:00

abstract：:Many high threshold, voltage-gated Ca2+ channels, including the dihydropyridine-sensitive class (L-type), inactivate in response not only to voltage, but also to entry of Ca2+. Despite the physiological importance of this Ca(2+)-sensitive inactivation, its molecular mechanism is understood only in broad outline. We no...

journal_title：Neuron

authors： Imredy JP,Yue DT

更新日期：1994-06-01 00:00:00

abstract：:In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...

journal_title：Neuron

authors： Chen WR,Xiong W,Shepherd GM

更新日期：2000-03-01 00:00:00

abstract：:NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...

journal_title：Neuron

authors： Chen BS,Roche KW

更新日期：2009-05-28 00:00:00

abstract：:Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion ...

journal_title：Neuron

authors： Tombola F,Pathak MM,Isacoff EY

更新日期：2005-12-08 00:00:00

abstract：:The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by mot...

journal_title：Neuron

authors： De Marco Garcia NV,Jessell TM

更新日期：2008-01-24 00:00:00