Abstract：
:TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.
journal_name
Neuronjournal_title
Neuronauthors
Fine M,Li Xdoi
10.1016/j.neuron.2020.12.017subject
Has Abstractpub_date
2021-01-20 00:00:00pages
194-196issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30999-5journal_volume
109pub_type
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