Abstract:
:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex of awake mice during locomotion and quiet wakefulness. We found that the signal-to-noise ratio for sensory responses was improved during locomotion by two mechanisms: (1) a decrease in membrane potential variability leading to a reduction in background firing rates and (2) an enhancement in the amplitude and reliability of visually evoked subthreshold responses mediated by an increase in total conductance and a depolarization of the stimulus-evoked reversal potential. Consistent with the enhanced signal-to-noise ratio for visual responses during locomotion, we demonstrate that performance is improved in a visual detection task during this behavioral state.
journal_name
Neuronjournal_title
Neuronauthors
Bennett C,Arroyo S,Hestrin Sdoi
10.1016/j.neuron.2013.08.007subject
Has Abstractpub_date
2013-10-16 00:00:00pages
350-7issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00718-6journal_volume
80pub_type
杂志文章相关文献
NEURON文献大全abstract::To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons, and flies e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.029
更新日期:2013-10-02 00:00:00
abstract::The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.06.002
更新日期:2005-06-16 00:00:00
abstract::Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00085-6
更新日期:2004-03-04 00:00:00
abstract::Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(01)00199-4
更新日期:2001-01-01 00:00:00
abstract::Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.03.015
更新日期:2011-04-14 00:00:00
abstract::beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80179-8
更新日期:1996-09-01 00:00:00
abstract::Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.027
更新日期:2017-01-04 00:00:00
abstract::Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.02.018
更新日期:2018-03-07 00:00:00
abstract::The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability, but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.11.020
更新日期:2020-02-19 00:00:00
abstract::Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge relat...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.05.010
更新日期:2009-06-11 00:00:00
abstract::The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.10.043
更新日期:2015-12-02 00:00:00
abstract::The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80600-5
更新日期:1998-10-01 00:00:00
abstract::It has been postulated that selective temporal coordination between neurons and development of functional neuronal assemblies are fundamental for brain function and behavior. Still, there is little evidence that functionally relevant coordination emerges preferentially in neuronal assemblies directly controlling behav...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.047
更新日期:2013-09-04 00:00:00
abstract::Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.10.022
更新日期:2005-11-03 00:00:00
abstract::A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.04.010
更新日期:2013-06-05 00:00:00
abstract::Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse mod...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.09.010
更新日期:2020-12-09 00:00:00
abstract::In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00217-x
更新日期:2004-05-13 00:00:00
abstract::The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.11.006
更新日期:2011-12-08 00:00:00
abstract::Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.042
更新日期:2020-01-08 00:00:00
abstract::Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 l...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2004.12.007
更新日期:2004-12-16 00:00:00
abstract::Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.045
更新日期:2020-01-08 00:00:00
abstract::Building on Canada's strong traditions in neuroscience and ethics, neuroethics provides a backbone for the evolving Canadian Brain Research Strategy (CBRS) that, from the outset, incorporates ethically responsible discoveries in brain science into clinical, societal, educational, and commercial innovation. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.12.021
更新日期:2019-02-06 00:00:00
abstract::Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.008
更新日期:2005-07-21 00:00:00
abstract::Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00384-1
更新日期:2001-08-16 00:00:00
abstract::While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80432-8
更新日期:1998-01-01 00:00:00
abstract::Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.03.021
更新日期:2020-06-17 00:00:00
abstract::Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00147-1
更新日期:2000-12-01 00:00:00
abstract::Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.006
更新日期:2019-12-18 00:00:00
abstract::Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90071-k
更新日期:1992-12-01 00:00:00
abstract::The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.04.024
更新日期:2005-06-02 00:00:00