Abstract：
:In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.
journal_name
Neuronjournal_title
Neuronauthors
Cahill MK,Huang EJdoi
10.1016/j.neuron.2017.02.044subject
Has Abstractpub_date
2017-03-08 00:00:00pages
987-989issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30152-6journal_volume
93pub_type
杂志文章,评审相关文献
NEURON文献大全abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.01.035
更新日期：2014-03-05 00:00:00
abstract：:Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.06.014
更新日期：2009-07-16 00:00:00
abstract：:The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.07.007
更新日期：2013-07-24 00:00:00
abstract：:Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.05.032
更新日期：2020-08-19 00:00:00
abstract：:The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin prep...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90015-2
更新日期：1995-12-01 00:00:00
abstract：:The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unkn...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.08.013
更新日期：2010-10-06 00:00:00
abstract：:Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90312-f
更新日期：1993-02-01 00:00:00
abstract：:Input comparison is thought to occur in many neuronal circuits, including the hippocampus, where functionally important interactions between the Schaffer collateral and perforant pathways have been hypothesized. We investigated this idea using multisite, whole-cell recordings and Ca2+ imaging and found that properly t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.03.007
更新日期：2009-04-16 00:00:00
abstract：:Phorbol esters and purified protein kinase C (PKC) have been shown to down-modulate the voltage-dependent Na+ channels expressed in Xenopus oocytes injected with chick brain RNA. We used the two-electrode voltage-clamp technique to demonstrate that a Na+ channel expressed in oocytes injected with RNA coding for the al...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90131-i
更新日期：1991-01-01 00:00:00
abstract：:Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00318-x
更新日期：2001-06-01 00:00:00
abstract：:The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.06.017
更新日期：2016-08-03 00:00:00
abstract：:The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.01.027
更新日期：2013-03-20 00:00:00
abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80850-8
更新日期：1999-10-01 00:00:00
abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00143-6
更新日期：2004-04-08 00:00:00
abstract：:Our understanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of APP to generate amyloid-beta (Abeta), is regulated in Alzheimer's disease (AD) remains incomplete. In this issue of Neuron, O'Connor and coworkers show how energy deprivation, a potential risk factor in AD, tr...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2008.12.010
更新日期：2008-12-26 00:00:00
abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.01.023
更新日期：2017-02-22 00:00:00
abstract：:In this issue of Neuron, Katsuki and colleagues show that cell-autonomous mechanisms divide Drosophila axons into proximal and distal compartments. Axon guidance receptors selectively localize to one compartment. A diffusion barrier exists near the compartment boundary, suggesting that it may have properties like thos...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.10.011
更新日期：2009-10-29 00:00:00
abstract：:Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.01.044
更新日期：2005-03-24 00:00:00
abstract：:The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving cerebellum and retina. Purkinje cell death in pcd is dramatic, as >99% of Purkinje neurons are lost in 3 weeks. Loss of function of Nna1 causes pcd, and Nna1 is a highly conserved zinc carboxypeptidase. To determine the bas...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.05.024
更新日期：2010-06-24 00:00:00
abstract：:Previous research suggests that synchronous neural activity underlies perceptual grouping of visual image features. The generality of this mechanism is unclear, however, as previous studies have focused on pairs of neurons with overlapping or collinear receptive fields. By sampling more broadly and employing stimuli t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.03.002
更新日期：2005-04-21 00:00:00
abstract：:In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.03.012
更新日期：2018-03-21 00:00:00
abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.08.007
更新日期：2013-10-16 00:00:00
abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.06.017
更新日期：2007-07-05 00:00:00
abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.11.030
更新日期：2010-12-22 00:00:00
abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.03.003
更新日期：2015-04-08 00:00:00
abstract：:Huntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, select...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.021
更新日期：2011-05-12 00:00:00
abstract：:Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90159-0
更新日期：1995-09-01 00:00:00
abstract：:Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, C...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.09.022
更新日期：2014-10-22 00:00:00
abstract：:Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90111-p
更新日期：1992-01-01 00:00:00
abstract：:The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarized transport; however, the sorting mechanism to exclude dendritic cargo from the axon is unclear. We show that the dynein regulator...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.01.022
更新日期：2016-02-03 00:00:00
