Abstract：
:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate mostly in complex cells. These responses stand clear of the noise, whose amplitude decreases as 1/frequency, and yield high-resolution maps of orientation preference and retinotopy. We first show how these maps are combined to yield the responses to focal, oriented stimuli. We then study the evolution of the oscillating activity in space and time. In the orientation domain, it is a standing wave. In the spatial domain, it is a traveling wave propagating at 0.2-0.5 m/s. These different dynamics indicate a fundamental distinction in the circuits underlying selectivity for position and orientation, two key stimulus attributes.
journal_name
Neuronjournal_title
Neuronauthors
Benucci A,Frazor RA,Carandini Mdoi
10.1016/j.neuron.2007.06.017subject
Has Abstractpub_date
2007-07-05 00:00:00pages
103-17issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00447-3journal_volume
55pub_type
杂志文章相关文献
NEURON文献大全abstract：:Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.09.029
更新日期：2006-11-22 00:00:00
abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.038
更新日期：2014-09-17 00:00:00
abstract：:When learning to achieve a goal through a complex series of actions, humans often group several actions into a subroutine and evaluate whether the subroutine achieved a specific subgoal. A new study reports brain responses consistent with such "hierarchical reinforcement learning." ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.07.004
更新日期：2011-07-28 00:00:00
abstract：:Understanding the neural basis of adaptation (repetition suppression) is critical for interpreting fMRI-adaptation experiments. Sawamura and colleagues provide a critical stepping-stone by elucidating the relation between neural adaptation and response selectivity. They find some cross-adaptation by two different stim...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2006.01.004
更新日期：2006-01-19 00:00:00
abstract：:Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates voca...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.12.025
更新日期：2016-01-20 00:00:00
abstract：:In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.015
更新日期：2016-04-20 00:00:00
abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.01.032
更新日期：2012-04-12 00:00:00
abstract：:To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00048-0
更新日期：2004-02-19 00:00:00
abstract：:Little is known about the molecular mechanisms underlying differences in the ligand binding properties of AMPA, kainate, and NMDA subtype glutamate receptors. Crystal structures of the GluR5 and GluR6 kainate receptor ligand binding cores in complexes with glutamate, 2S,4R-4-methylglutamate, kainate, and quisqualate h...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.01.031
更新日期：2005-02-17 00:00:00
abstract：:Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the ma...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.04.019
更新日期：2016-06-01 00:00:00
abstract：:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.007
更新日期：2008-04-10 00:00:00
abstract：:Neurons can maintain stable synaptic connections across adult life. However, the signals that regulate expression of synaptic proteins in the mature brain are incompletely understood. Here, we describe a transcriptional feedback loop between the biosynthesis and repertoire of specific phospholipids and the synaptic ve...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.015
更新日期：2019-02-20 00:00:00
abstract：:At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the tran...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00563-4
更新日期：2003-09-11 00:00:00
abstract：:Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external enviro...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.10.013
更新日期：2018-10-24 00:00:00
abstract：:Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81095-8
更新日期：1999-02-01 00:00:00
abstract：:Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.001
更新日期：2016-04-20 00:00:00
abstract：:We used fMRI to investigate how moment-to-moment neural activity contributes to success or failure on individual trials of a visual working memory (WM) task. We found that different nodes of a distributed cortical network were activated to a greater extent for correct compared to incorrect trials during stimulus encod...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00817-6
更新日期：2002-08-29 00:00:00
abstract：:GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.043
更新日期：2017-01-18 00:00:00
abstract：:Neurons compensate their synaptic strengths to global changes in network activity. In this issue of Neuron, Lee et al. (2013) provide evidence in mature hippocampal networks that this homeostatic plasticity is achieved uniquely at the mossy fiber synapses on CA3 neurons. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.12.024
更新日期：2013-01-09 00:00:00
abstract：:Adolescence is often described as a period of heightened reactivity to emotions paired with reduced regulatory capacities, a combination suggested to contribute to risk-taking and susceptibility to peer influence during puberty. However, no longitudinal research has definitively linked these behavioral changes to unde...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.02.019
更新日期：2011-03-10 00:00:00
abstract：:Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.01.003
更新日期：2015-02-18 00:00:00
abstract：:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.02.040
更新日期：2016-04-06 00:00:00
abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.04.019
更新日期：2017-05-03 00:00:00
abstract：:Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.10.017
更新日期：2020-01-22 00:00:00
abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.12.013
更新日期：2009-01-29 00:00:00
abstract：:The debate over the nature of mechanisms leading to the establishment of synaptic specificity has engaged neuroscientists for the best part of a century. In this issue of Neuron, Balaskas et al. (2019) provide new evidence in favor of the role of positional strategies in the organization of sensory-motor circuits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.05.046
更新日期：2019-06-19 00:00:00
abstract：:Hundreds of G protein-coupled receptors (GPCRs) and at least six GPCR kinases have been identified, but the only GPCR phosphatase that has been definitively demonstrated is the rhodopsin phosphatase encoded by the rdgC locus of Drosophila. Mutations in rdgC result in defects in termination of the light response and ca...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00538-4
更新日期：2001-12-20 00:00:00
abstract：:Locomotor activity in many species undergoes pronounced alterations in early postnatal life, and environmental cues may be responsible for modifying this process. To determine how these events are reflected in the nervous system, we studied rats reared under two different conditions-the presence or absence of gravity-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81164-2
更新日期：2000-05-01 00:00:00
abstract：:Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated tha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00298-7
更新日期：2001-05-01 00:00:00
abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.05.006
更新日期：2014-07-02 00:00:00
