Generating X: formation of the optic chiasm.

abstract：:We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...

journal_title：Neuron

authors： Hasson U,Harel M,Levy I,Malach R

更新日期：2003-03-27 00:00:00

abstract：:Circadian pacemaker neurons contain a molecular clock that oscillates with a period of approximately 24 hr, controlling circadian rhythms of behavior. Pacemaker neurons respond to visual system inputs for clock resetting, but, unlike other neurons, have not been reported to transmit rapid signals to their targets. Her...

journal_title：Neuron

authors： Mazzoni EO,Desplan C,Blau J

更新日期：2005-01-20 00:00:00

abstract：:Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schiz...

journal_title：Neuron

authors： Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

更新日期：2014-01-22 00:00:00

abstract：:Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...

journal_title：Neuron

authors： Hanson MG,Landmesser LT

更新日期：2004-09-02 00:00:00

abstract：:Despite the fact that strong trial-to-trial correlated variability in responses has been reported in many cortical areas, recent evidence suggests that neuronal correlations are much lower than previously thought. Here, we used multicontact laminar probes to revisit the issue of correlated variability in primary visua...

journal_title：Neuron

authors： Hansen BJ,Chelaru MI,Dragoi V

更新日期：2012-11-08 00:00:00

abstract：:The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...

journal_title：Neuron

authors： Gilbert CD,Li W

更新日期：2012-07-26 00:00:00

abstract：:Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....

journal_title：Neuron

authors： van den Maagdenberg AM,Pietrobon D,Pizzorusso T,Kaja S,Broos LA,Cesetti T,van de Ven RC,Tottene A,van der Kaa J,Plomp JJ,Frants RR,Ferrari MD

更新日期：2004-03-04 00:00:00

abstract：:Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However...

journal_title：Neuron

authors： Card JP,Whealy ME,Robbins AK,Moore RY,Enquist LW

更新日期：1991-06-01 00:00:00

abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

journal_title：Neuron

authors： Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

更新日期：1997-08-01 00:00:00

abstract：:In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...

journal_title：Neuron

authors： Corbit VL,Ahmari SE,Gittis AH

更新日期：2017-10-11 00:00:00

abstract：:Both human speech and animal vocal signals contain frequency-modulated (FM) sounds. Although central auditory neurons that selectively respond to the direction of frequency modulation are known, the synaptic mechanisms underlying the generation of direction selectivity (DS) remain elusive. Here we show the emergence o...

journal_title：Neuron

authors： Kuo RI,Wu GK

更新日期：2012-03-08 00:00:00

abstract：:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...

journal_title：Neuron

authors： Hyman BT

更新日期：2014-06-18 00:00:00

abstract：:The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...

journal_title：Neuron

authors： Na Y,Park S,Lee C,Kim DK,Park JM,Sockanathan S,Huganir RL,Worley PF

更新日期：2016-08-03 00:00:00

abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

journal_title：Neuron

authors： Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

更新日期：2003-10-30 00:00:00

abstract：:TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-relat...

journal_title：Neuron

authors： Xu XZ,Chien F,Butler A,Salkoff L,Montell C

更新日期：2000-06-01 00:00:00

abstract：:This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...

journal_title：Neuron

authors： Petersen RS,Panzeri S,Diamond ME

更新日期：2001-11-08 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...

journal_title：Neuron

authors： Taha S,Hanover JL,Silva AJ,Stryker MP

更新日期：2002-10-24 00:00:00

abstract：:Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...

journal_title：Neuron

authors： Tse FW,Tse A,Hille B,Horstmann H,Almers W

更新日期：1997-01-01 00:00:00

abstract：:To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of hori...

journal_title：Neuron

authors： Vélez-Fort M,Bracey EF,Keshavarzi S,Rousseau CV,Cossell L,Lenzi SC,Strom M,Margrie TW

更新日期：2018-04-04 00:00:00

abstract：:Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...

journal_title：Neuron

authors： Frith U

更新日期：2001-12-20 00:00:00

abstract：:Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of the Dp(16) mouse mod...

journal_title：Neuron

authors： Pinto B,Morelli G,Rastogi M,Savardi A,Fumagalli A,Petretto A,Bartolucci M,Varea E,Catelani T,Contestabile A,Perlini LE,Cancedda L

更新日期：2020-12-09 00:00:00

abstract：:Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...

journal_title：Neuron

authors： Rainer G

更新日期：2007-02-01 00:00:00

abstract：:Among the diverse interneuron subtypes in the neocortex, chandelier cells (ChCs) are the only population that selectively innervate pyramidal neurons (PyNs) at their axon initial segment (AIS), the site of action potential initiation, allowing them to exert powerful control over PyN output. Yet, mechanisms underlying ...

journal_title：Neuron

authors： Tai Y,Gallo NB,Wang M,Yu JR,Van Aelst L

更新日期：2019-04-17 00:00:00

abstract：:N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is relatively resistant to the N channel antagonist omega-conotoxin GVIA. We studied the sensitivity of glutamatergic synaptic transmission ...

journal_title：Neuron

authors： Luebke JI,Dunlap K,Turner TJ

更新日期：1993-11-01 00:00:00

abstract：:Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...

journal_title：Neuron

authors： Peineau S,Taghibiglou C,Bradley C,Wong TP,Liu L,Lu J,Lo E,Wu D,Saule E,Bouschet T,Matthews P,Isaac JT,Bortolotto ZA,Wang YT,Collingridge GL

更新日期：2007-03-01 00:00:00

abstract：:Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...

journal_title：Neuron

authors： Romo R,Hernández A,Zainos A,Brody CD,Lemus L

更新日期：2000-04-01 00:00:00

abstract：:Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

journal_title：Neuron

authors： Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

更新日期：1988-12-01 00:00:00

abstract：:The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...

journal_title：Neuron

authors： Adolphs R

更新日期：2016-06-15 00:00:00

abstract：:Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have been described. Using a mass...

journal_title：Neuron

authors： Hertz NT,Adams EL,Weber RA,Shen RJ,O'Rourke MK,Simon DJ,Zebroski H,Olsen O,Morgan CW,Mileur TR,Hitchcock AM,Sinnott Armstrong NA,Wainberg M,Bassik MC,Molina H,Wells JA,Tessier-Lavigne M

更新日期：2019-08-07 00:00:00