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Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules.

Abstract：

:Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also required at much earlier stages for spinal motoneurons to accurately execute their first major dorsal-ventral pathfinding decision. Blockade or slowing of rhythmic bursting activity also prevents the normal expression patterns of EphA4 and polysialic acid on NCAM, which may contribute to the pathfinding errors observed. More prolonged (E2-5) blockade resulted in a downregulation of LIM homeodomain transcription factors, but since this occurred only after the pathfinding errors and alterations in guidance molecules, it cannot have contributed to them.

journal_name

Neuron

journal_title

Neuron

authors

Hanson MG,Landmesser LT

doi

10.1016/j.neuron.2004.08.018

subject

Has Abstract

pub_date

2004-09-02 00:00:00

pages

687-701

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896627304005239

journal_volume

43

pub_type

杂志文章

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