Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...

journal_title：Neuron

authors： Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

更新日期：2006-09-21 00:00:00

abstract：:While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...

journal_title：Neuron

authors： Frade JM,Barde YA

更新日期：1998-01-01 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...

journal_title：Neuron

authors： Shackleford GM,Willert K,Wang J,Varmus HE

更新日期：1993-11-01 00:00:00

abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...

journal_title：Neuron

authors： Kay LM,Beshel J,Martin C

更新日期：2006-08-03 00:00:00

abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...

journal_title：Neuron

authors： Caceres A,Mautino J,Kosik KS

更新日期：1992-10-01 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse chan...

journal_title：Neuron

authors： Wang GX,Smith SJ,Mourrain P

更新日期：2014-12-17 00:00:00

abstract：:Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...

journal_title：Neuron

authors： Carew TJ,Magsamen SH

更新日期：2010-09-09 00:00:00

abstract：:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...

journal_title：Neuron

authors： Gonzalez-Castillo J,Bandettini PA

更新日期：2015-06-17 00:00:00

abstract：:During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...

journal_title：Neuron

authors： Craven SE,El-Husseini AE,Bredt DS

更新日期：1999-03-01 00:00:00

abstract：:The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamoc...

journal_title：Neuron

authors： Dufour A,Seibt J,Passante L,Depaepe V,Ciossek T,Frisén J,Kullander K,Flanagan JG,Polleux F,Vanderhaeghen P

更新日期：2003-07-31 00:00:00

abstract：:In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...

journal_title：Neuron

authors： Lodovichi C,Belluscio L,Katz LC

更新日期：2003-04-24 00:00:00

abstract：:Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this...

journal_title：Neuron

authors： Salamone JD,Correa M

更新日期：2012-11-08 00:00:00

abstract：:Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent l...

journal_title：Neuron

authors： Woolf CJ

更新日期：2003-04-24 00:00:00

abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...

journal_title：Neuron

authors： Wu YE,Huo L,Maeder CI,Feng W,Shen K

更新日期：2013-06-19 00:00:00

abstract：:Rostrocaudal polarity of the tectum is first detectable at embryonic day 2 (E2) in the chick by the rostrocaudal gradient of en expression. When ectopic tectum is produced by heterotopic transplantation at E2 in the diencephalon, the gradient of en expression is inverted from the host polarity by environmental influen...

journal_title：Neuron

authors： Itasaki N,Nakamura H

更新日期：1992-04-01 00:00:00

abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

journal_title：Neuron

authors： Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

更新日期：2015-04-22 00:00:00

abstract：:Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon...

journal_title：Neuron

authors： Guo C,Witter L,Rudolph S,Elliott HL,Ennis KA,Regehr WG

更新日期：2016-09-21 00:00:00

abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...

journal_title：Neuron

authors： Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

更新日期：2014-07-02 00:00:00

abstract：:alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of...

journal_title：Neuron

authors： Legan PK,Lukashkina VA,Goodyear RJ,Kössi M,Russell IJ,Richardson GP

更新日期：2000-10-01 00:00:00

abstract：:In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...

journal_title：Neuron

authors： Pesaran B,Movshon JA

更新日期：2008-05-08 00:00:00

abstract：:Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...

journal_title：Neuron

authors： Althaus AL,Parent JM

更新日期：2012-09-20 00:00:00

abstract：:To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...

journal_title：Neuron

authors： Yao WD,Gainetdinov RR,Arbuckle MI,Sotnikova TD,Cyr M,Beaulieu JM,Torres GE,Grant SG,Caron MG

更新日期：2004-02-19 00:00:00

abstract：:Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN...

journal_title：Neuron

authors： Banerjee SB,Gutzeit VA,Baman J,Aoued HS,Doshi NK,Liu RC,Ressler KJ

更新日期：2017-07-05 00:00:00

abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

journal_title：Neuron

authors： Mitchell SJ,Silver RA

更新日期：2003-05-08 00:00:00

abstract：:Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...

journal_title：Neuron

authors： Dunaevsky A

更新日期：2004-10-14 00:00:00

abstract：:The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...

journal_title：Neuron

authors： Pape HC

更新日期：2010-08-26 00:00:00

abstract：:Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...

journal_title：Neuron

authors： Müller M,Genç Ö,Davis GW

更新日期：2015-03-04 00:00:00

abstract：:Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...

journal_title：Neuron

authors： Gabbiani F,Jones PW

更新日期：2011-06-23 00:00:00