The mysterious motivational functions of mesolimbic dopamine.

Abstract:

:Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it is important to distinguish between aspects of motivation that are differentially affected by dopaminergic manipulations. For example, accumbens dopamine does not mediate primary food motivation or appetite, but is involved in appetitive and aversive motivational processes including behavioral activation, exertion of effort, approach behavior, sustained task engagement, Pavlovian processes, and instrumental learning. In this review, we discuss the complex roles of dopamine in behavioral functions related to motivation.

journal_name

Neuron

journal_title

Neuron

authors

Salamone JD,Correa M

doi

10.1016/j.neuron.2012.10.021

subject

Has Abstract

pub_date

2012-11-08 00:00:00

pages

470-85

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(12)00941-5

journal_volume

76

pub_type

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