Abstract:
:alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of wild-type and alpha-tectorin mutant mice are tuned, but the alpha-tectorin mutants are 35 dB less sensitive. Basilar membrane responses of wild-type mice exhibit a second resonance, indicating that the tectorial membrane provides an inertial mass against which outer hair cells can exert forces. Cochlear microphonics recorded in alpha-tectorin mutants differ in both phase and symmetry relative to those of wild-type mice. Thus, the tectorial membrane ensures that outer hair cells can effectively respond to basilar membrane motion and that feedback is delivered with the appropriate gain and timing required for amplification.
journal_name
Neuronjournal_title
Neuronauthors
Legan PK,Lukashkina VA,Goodyear RJ,Kössi M,Russell IJ,Richardson GPdoi
10.1016/s0896-6273(00)00102-1subject
Has Abstractpub_date
2000-10-01 00:00:00pages
273-85issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(00)00102-1journal_volume
28pub_type
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