Abstract:
:Two cDNAs encoding novel GABAA receptor subunits were isolated from a rat brain library. These subunits, gamma 2 and delta, share approximately 35% sequence identity with alpha and beta subunits and form functional GABA-gated chloride channels when expressed alone in vitro. The gamma 2 subunit is the rat homolog of the human gamma 2 subunit recently shown to be important for benzodiazepine pharmacology. Cellular localization of the mRNAs encoding the gamma 2 and delta subunits in rat brain revealed that largely distinct neuronal subpopulations express the two subunits. The delta subunit distribution resembles that of the high affinity GABAA receptor labeled with [3H]muscimol; the gamma 2 subunit distribution resembles that of GABAA/benzodiazepine receptors labeled with [3H]flunitrazepam. These findings have implications for the composition of two different GABAA receptor subtypes and for information processing in networks using GABA for signaling.
journal_name
Neuronjournal_title
Neuronauthors
Shivers BD,Killisch I,Sprengel R,Sontheimer H,Köhler M,Schofield PR,Seeburg PHdoi
10.1016/0896-6273(89)90257-2subject
Has Abstractpub_date
1989-09-01 00:00:00pages
327-37issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(89)90257-2journal_volume
3pub_type
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