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Getting RIP'd Stunts Your Growth.

Abstract：

:The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA activation and growth inhibition.

journal_name

Neuron

journal_title

Neuron

authors

Ceni C,Barker PA

doi

10.1016/j.neuron.2005.06.002

subject

Has Abstract

pub_date

2005-06-16 00:00:00

pages

839-40

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(05)00479-4

journal_volume

46

pub_type

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