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The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.

Abstract：

:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes an ion channel and show that it is constitutively active when mutated. These mutations disrupt different regions of the channel and have different effects on its gating. The UNC-105 channels are permeable to small monovalent cations but show voltage-dependent block by Ca2+ and Mg2+. Amiloride also produces voltage-dependent block, consistent with a single binding site 65% into the electric field. Mammalian cells expressing the mutant channels accumulate membranous whorls and multicompartment vacuoles, hallmarks of degenerin-induced cell death across species.

journal_name

Neuron

journal_title

Neuron

authors

García-Añoveros J,García JA,Liu JD,Corey DP

doi

10.1016/s0896-6273(00)80503-6

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

1231-41

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(00)80503-6

journal_volume

20

pub_type

杂志文章

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