Abstract:
:Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are locally projecting intersegmental commissural neurons. In Evx1 mutant embryos, the majority of V0 interneurons fail to extend commissural axons. Instead, they adopt an En1-like ipsilateral axonal projection and ectopically express En1, indicating that V0 interneurons are transfated to a V1 identity. Conversely, misexpression of Evx1 represses En1, suggesting that Evx1 may suppress the V1 interneuron differentiation program. Our findings demonstrate that Evx1 is a postmitotic determinant of V0 interneuron identity and reveal a critical postmitotic phase for neuronal determination in the developing spinal cord.
journal_name
Neuronjournal_title
Neuronauthors
Moran-Rivard L,Kagawa T,Saueressig H,Gross MK,Burrill J,Goulding Mdoi
10.1016/s0896-6273(01)00213-6subject
Has Abstractpub_date
2001-02-01 00:00:00pages
385-99issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00213-6journal_volume
29pub_type
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