Abstract：
:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus granule cells (DG GCs) and lateral entorhinal cortex (LEC) neurons across days to understand how sensory representations are modified by experience. We found representations of odors in DG GCs that required synaptic input from the LEC. Odor classification accuracy in DG GCs correlated with future behavioral discrimination. In associative learning, DG GCs, more so than LEC neurons, changed their responses to odor stimuli, increasing the distance in neural representations between stimuli, responding more to the conditioned and less to the unconditioned odorant. Thus, with learning, DG GCs amplify the decodability of cortical representations of important stimuli, which may facilitate information storage to guide behavior.
journal_name
Neuronjournal_title
Neuronauthors
Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MAdoi
10.1016/j.neuron.2020.04.002subject
Has Abstractpub_date
2020-07-08 00:00:00pages
173-184.e6issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30271-3journal_volume
107pub_type
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