Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortex.


:Neuronal cell migration in the developing neocortex relies on the Reelin signaling cascade to establish the characteristic "inside out" lamination pattern. In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the effects of Reelin on neuronal cell migration.






Gaiano N




Has Abstract


2008-10-23 00:00:00
















  • Epimetronomics: m6A Marks the Tempo of Corticogenesis.

    abstract::Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...


    pub_type: 评论,杂志文章


    authors: Boles NC,Temple S

    更新日期:2017-11-15 00:00:00

  • Four GABAergic interneurons impose feeding restraint in Drosophila.

    abstract::Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...


    pub_type: 杂志文章


    authors: Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

    更新日期:2014-07-02 00:00:00

  • A pair of interneurons influences the choice between feeding and locomotion in Drosophila.

    abstract::The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...


    pub_type: 杂志文章


    authors: Mann K,Gordon MD,Scott K

    更新日期:2013-08-21 00:00:00

  • Neuronal Inhibition under the Spotlight.

    abstract::In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...


    pub_type: 评论,杂志文章


    authors: Mortensen M,Smart TG

    更新日期:2015-12-02 00:00:00

  • What Cascade Spreading Models Can Teach Us about the Brain.

    abstract::The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...


    pub_type: 评论,杂志文章


    authors: Gonzalez-Castillo J,Bandettini PA

    更新日期:2015-06-17 00:00:00

  • Seeing Anew through Interneuron Transplantation.

    abstract::Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...


    pub_type: 评论,杂志文章


    authors: Levine JN,Gu Y,Cang J

    更新日期:2015-05-20 00:00:00

  • Behavioral flexibility and the frontal lobe.

    abstract::Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...


    pub_type: 评论,杂志文章


    authors: Rainer G

    更新日期:2007-02-01 00:00:00

  • Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

    abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...


    pub_type: 杂志文章


    authors: Whistler JL,Chuang HH,Chu P,Jan LY,von Zastrow M

    更新日期:1999-08-01 00:00:00

  • Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes.

    abstract::Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, ...


    pub_type: 杂志文章


    authors: Jové V,Gong Z,Hol FJH,Zhao Z,Sorrells TR,Carroll TS,Prakash M,McBride CS,Vosshall LB

    更新日期:2020-12-23 00:00:00

  • Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation.

    abstract::The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between tonic and phasic dopamine neuron act...


    pub_type: 杂志文章


    authors: Soden ME,Jones GL,Sanford CA,Chung AS,Güler AD,Chavkin C,Luján R,Zweifel LS

    更新日期:2013-11-20 00:00:00

  • Calcium signaling in dendrites and spines: practical and functional considerations.

    abstract::Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...


    pub_type: 杂志文章,评审


    authors: Higley MJ,Sabatini BL

    更新日期:2008-09-25 00:00:00

  • Targeting Homer1a for Rapid Antidepressant Effects.

    abstract::In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...


    pub_type: 评论,杂志文章


    authors: Albert PR

    更新日期:2019-10-23 00:00:00

  • The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.

    abstract::The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate re...


    pub_type: 杂志文章


    authors: Savas JN,Ribeiro LF,Wierda KD,Wright R,DeNardo-Wilke LA,Rice HC,Chamma I,Wang YZ,Zemla R,Lavallée-Adam M,Vennekens KM,O'Sullivan ML,Antonios JK,Hall EA,Thoumine O,Attie AD,Yates JR 3rd,Ghosh A,de Wit J

    更新日期:2015-08-19 00:00:00

  • Hunting for excitement: NMDA receptors in Huntington's disease.

    abstract::Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...


    pub_type: 评论,杂志文章


    authors: Ellerby LM

    更新日期:2002-03-14 00:00:00

  • Breaking boundaries in neural-immune interactions.

    abstract::For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...




    authors: McAllister AK,van de Water J

    更新日期:2009-10-15 00:00:00

  • Visinin: a novel calcium binding protein expressed in retinal cone cells.

    abstract::Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...


    pub_type: 杂志文章


    authors: Yamagata K,Goto K,Kuo CH,Kondo H,Miki N

    更新日期:1990-03-01 00:00:00

  • Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons.

    abstract::The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...


    pub_type: 杂志文章


    authors: Weissbourd B,Ren J,DeLoach KE,Guenthner CJ,Miyamichi K,Luo L

    更新日期:2014-08-06 00:00:00

  • Functional dissection of the Drosophila mushroom bodies by selective feminization of genetically defined subcompartments.

    abstract::Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved...


    pub_type: 杂志文章


    authors: O'Dell KM,Armstrong JD,Yang MY,Kaiser K

    更新日期:1995-07-01 00:00:00

  • Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues.

    abstract::Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...


    pub_type: 杂志文章


    authors: Bozek K,Wei Y,Yan Z,Liu X,Xiong J,Sugimoto M,Tomita M,Pääbo S,Sherwood CC,Hof PR,Ely JJ,Li Y,Steinhauser D,Willmitzer L,Giavalisco P,Khaitovich P

    更新日期:2015-02-18 00:00:00

  • Dendritic h channelopathy in epileptogenesis.

    abstract::Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...


    pub_type: 杂志文章


    authors: Dyhrfjeld-Johnsen J,Soltesz I

    更新日期:2004-10-28 00:00:00

  • Adaptive Prediction Error Coding in the Human Midbrain and Striatum Facilitates Behavioral Adaptation and Learning Efficiency.

    abstract::Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the ma...


    pub_type: 杂志文章


    authors: Diederen KM,Spencer T,Vestergaard MD,Fletcher PC,Schultz W

    更新日期:2016-06-01 00:00:00

  • Cellular basis for the response to second-order motion cues in Y retinal ganglion cells.

    abstract::We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...


    pub_type: 杂志文章


    authors: Demb JB,Zaghloul K,Sterling P

    更新日期:2001-11-20 00:00:00

  • Neural stem cells: historical perspective and future prospects.

    abstract::How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...


    pub_type: 历史文章,杂志文章


    authors: Breunig JJ,Haydar TF,Rakic P

    更新日期:2011-05-26 00:00:00

  • Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value.

    abstract::Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection...


    pub_type: 杂志文章


    authors: Lak A,Okun M,Moss MM,Gurnani H,Farrell K,Wells MJ,Reddy CB,Kepecs A,Harris KD,Carandini M

    更新日期:2020-02-19 00:00:00

  • No Nogo: now where to go?

    abstract::Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent l...


    pub_type: 评论,杂志文章,评审


    authors: Woolf CJ

    更新日期:2003-04-24 00:00:00

  • In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum.

    abstract::Fibroblastic 3T3 and endocrine RIN cells were genetically modified by infection with a recombinant retrovirus encoding the form I of human tyrosine hydroxylase (TH) and selection in tyrosine-free medium. These cells were grafted to rats unilaterally lesioned with 6-hydroxy-dopamine. Both cell types survived implantati...


    pub_type: 杂志文章


    authors: Horellou P,Brundin P,Kalén P,Mallet J,Björklund A

    更新日期:1990-10-01 00:00:00

  • The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration.

    abstract::Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...


    pub_type: 杂志文章


    authors: Isaacman-Beck J,Schneider V,Franzini-Armstrong C,Granato M

    更新日期:2015-11-18 00:00:00

  • The Contribution of Area MT to Visual Motion Perception Depends on Training.

    abstract::Perceptual decisions require the transformation of raw sensory inputs into cortical representations suitable for stimulus discrimination. One of the best-known examples of this transformation involves the middle temporal area (MT) of the primate visual cortex. Area MT provides a robust representation of stimulus motio...


    pub_type: 杂志文章


    authors: Liu LD,Pack CC

    更新日期:2017-07-19 00:00:00

  • Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

    abstract::The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...


    pub_type: 杂志文章


    authors: Zuchero YJ,Chen X,Bien-Ly N,Bumbaca D,Tong RK,Gao X,Zhang S,Hoyte K,Luk W,Huntley MA,Phu L,Tan C,Kallop D,Weimer RM,Lu Y,Kirkpatrick DS,Ernst JA,Chih B,Dennis MS,Watts RJ

    更新日期:2016-01-06 00:00:00

  • Cerebellar Control of Reach Kinematics for Endpoint Precision.

    abstract::The cerebellum is well appreciated to impart speed, smoothness, and precision to skilled movements such as reaching. How these functions are executed by the final output stage of the cerebellum, the cerebellar nuclei, remains unknown. Here, we identify a causal relationship between cerebellar output and mouse reach ki...


    pub_type: 杂志文章


    authors: Becker MI,Person AL

    更新日期:2019-07-17 00:00:00