Abstract：
:Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activation of specific dopamine neurons induces both learning and odor-specific synaptic depression. The plasticity induction strictly depends on the temporal order of the two stimuli, replicating the logical requirement for associative learning. Furthermore, we reveal that dopamine action is confined to and distinct across different anatomical compartments of the mushroom body lobes. Finally, we find that overlap between sparse representations of different odors defines both stimulus specificity of the plasticity and generalizability of associative memories across odors. Thus, the plasticity we find here not only manifests important features of associative learning but also provides general insights into how a sparse sensory code is read out.
journal_name
Neuronjournal_title
Neuronauthors
Hige T,Aso Y,Modi MN,Rubin GM,Turner GCdoi
10.1016/j.neuron.2015.11.003subject
Has Abstractpub_date
2015-12-02 00:00:00pages
985-998issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00982-4journal_volume
88pub_type
杂志文章相关文献
NEURON文献大全abstract：:LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.08.022
更新日期：2012-09-20 00:00:00
abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.03.017
更新日期：2012-06-07 00:00:00
abstract：:Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90114-s
更新日期：1992-01-01 00:00:00
abstract：:In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.01.021
更新日期：2015-02-04 00:00:00
abstract：:We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00622-0
更新日期：2002-03-28 00:00:00
abstract：:Adaptation or gain control allows sensory neurons to encode diverse stimuli using a limited range of output signals. Rod vision exemplifies a general challenge facing adaptational mechanisms-balancing the benefits of averaging to create a reliable signal for adaptation with the need to adapt rapidly and locally. The s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.031
更新日期：2008-03-27 00:00:00
abstract：:Calcium current types expressed in vertebrate spinal motoneurons have not been previously resolved. We have resolved three types in chick limb motoneurons identified by retrograde labeling and report that dramatic changes in their expression take place during development in vivo. T-, N-, and L-type calcium currents we...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90052-4
更新日期：1989-06-01 00:00:00
abstract：:Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.09.034
更新日期：2016-10-05 00:00:00
abstract：:The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.02.023
更新日期：2014-03-05 00:00:00
abstract：:The controversy about whether dopamine contributes to cell loss in Parkinson's disease takes a new turn as Mosharov et al. in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.04.010
更新日期：2009-04-30 00:00:00
abstract：:Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.06.008
更新日期：2008-07-31 00:00:00
abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.03.003
更新日期：2015-04-08 00:00:00
abstract：:Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80344-x
更新日期：1997-07-01 00:00:00
abstract：:The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.05.034
更新日期：2019-08-21 00:00:00
abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.01.035
更新日期：2014-03-05 00:00:00
abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.06.014
更新日期：2004-07-08 00:00:00
abstract：:Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.10.005
更新日期：2014-10-22 00:00:00
abstract：:Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting and overcome many limitations of non-viral tracers. Here, we summarize the viruses that have been developed for neural circuit mapping, and we provide a primer...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2020.07.010
更新日期：2020-09-23 00:00:00
abstract：:DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to develop a new Gi-coupled DREADD using the kappa-opioid receptor as a template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB)...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.03.065
更新日期：2015-05-20 00:00:00
abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.03.001
更新日期：2010-03-25 00:00:00
abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90152-x
更新日期：1994-01-01 00:00:00
abstract：:Regulation of synaptic strength is essential for neuronal information processing, but the molecular mechanisms that control changes in neuroexocytosis are only partially known. Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate n...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00932-7
更新日期：2002-09-26 00:00:00
abstract：:In this issue of Neuron, Winkowski and Knudsen reveal striking parallels between the attentional systems of the barn owl and the rhesus macaque. The observation of close similarities between the attentional systems of such distantly related organisms strongly suggest that key computational principles are at work. ...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2008.11.006
更新日期：2008-11-26 00:00:00
abstract：:During binocular rivalry, conflicting monocular images undergo alternating suppression. This study explores rivalry suppression by probing visual sensitivity during rivalry with various probe stimuli. When two faces engage in rivalry, sensitivity to face probes is reduced 4-fold during suppression. Rivaling global mot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.027
更新日期：2006-12-07 00:00:00
abstract：:We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00144-2
更新日期：2003-03-27 00:00:00
abstract：:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2020.07.020
更新日期：2020-09-09 00:00:00
abstract：:Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor re...
journal_title：Neuron
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuron.2009.10.018
更新日期：2009-12-10 00:00:00
abstract：:Membrane excitability is a fundamentally important feature for all excitable cells including both neurons and muscle cells. However, the background depolarizing conductances in excitable cells, especially in muscle cells, are not well characterized. Although mutations in transmembrane channel-like (TMC) proteins TMC1 ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.12.041
更新日期：2018-02-07 00:00:00
abstract：:Our understanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of APP to generate amyloid-beta (Abeta), is regulated in Alzheimer's disease (AD) remains incomplete. In this issue of Neuron, O'Connor and coworkers show how energy deprivation, a potential risk factor in AD, tr...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2008.12.010
更新日期：2008-12-26 00:00:00
abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.025
更新日期：2018-11-21 00:00:00
