Abstract:
:Calcium current types expressed in vertebrate spinal motoneurons have not been previously resolved. We have resolved three types in chick limb motoneurons identified by retrograde labeling and report that dramatic changes in their expression take place during development in vivo. T-, N-, and L-type calcium currents were distinguished on the basis of kinetics, voltage dependence, and unique pharmacological sensitivities. Developmental changes were characterized by studying motoneurons isolated from embryos at three stages spanning neuromuscular system development. T currents were dominant at the earliest stage. Motoneurons from embryos 2 days older showed much reduced T currents and much increased N and L currents. We suggest that mature motoneurons will be dominated by N- and L-type calcium currents and that T current may serve developmental roles.
journal_name
Neuronjournal_title
Neuronauthors
McCobb DP,Best PM,Beam KGdoi
10.1016/0896-6273(89)90052-4subject
Has Abstractpub_date
1989-06-01 00:00:00pages
1633-43issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(89)90052-4journal_volume
2pub_type
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