Development alters the expression of calcium currents in chick limb motoneurons.

Abstract:

:Calcium current types expressed in vertebrate spinal motoneurons have not been previously resolved. We have resolved three types in chick limb motoneurons identified by retrograde labeling and report that dramatic changes in their expression take place during development in vivo. T-, N-, and L-type calcium currents were distinguished on the basis of kinetics, voltage dependence, and unique pharmacological sensitivities. Developmental changes were characterized by studying motoneurons isolated from embryos at three stages spanning neuromuscular system development. T currents were dominant at the earliest stage. Motoneurons from embryos 2 days older showed much reduced T currents and much increased N and L currents. We suggest that mature motoneurons will be dominated by N- and L-type calcium currents and that T current may serve developmental roles.

journal_name

Neuron

journal_title

Neuron

authors

McCobb DP,Best PM,Beam KG

doi

10.1016/0896-6273(89)90052-4

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

1633-43

issue

6

eissn

0896-6273

issn

1097-4199

pii

0896-6273(89)90052-4

journal_volume

2

pub_type

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