Abstract：
:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow variations in oxygenation follow a cascade. First, they closely track changes in arteriole diameter. Second, interpretable functional connections arise when the ultra-slow changes in amplitude of γ-band neuronal oscillations, which are shared across even far-flung but synaptically connected brain regions, entrain the ∼0.1-Hz vasomotor oscillation in diameter of local arterioles. Significant confounds to estimates of functional connectivity arise from residual vasomotor activity as well as arteriole dynamics driven by self-generated movements and subcortical common modulatory inputs. Last, methodological limitations of fMRI can lead to spurious functional connections. The neuronal generator of ultra-slow variations in γ-band amplitude, including that associated with self-generated movements, remains an open issue.
journal_name
Neuronjournal_title
Neuronauthors
Drew PJ,Mateo C,Turner KL,Yu X,Kleinfeld Ddoi
10.1016/j.neuron.2020.07.020subject
Has Abstractpub_date
2020-09-09 00:00:00pages
782-804issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30564-Xjournal_volume
107pub_type
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