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abstract：:Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...

journal_title：Neuron

authors： Belujon P,Grace AA

更新日期：2011-09-08 00:00:00

abstract：:Sleep has many inherent benefits, including an important role in memory consolidation. In this issue of Neuron, Ngo et al. (2013b) demonstrate that appropriately timed sounds delivered during sleep can invigorate electrophysiological oscillations conducive to memory stabilization. ...

journal_title：Neuron

authors： Oudiette D,Santostasi G,Paller KA

更新日期：2013-05-08 00:00:00

abstract：:The mechanisms controlling the transition from neurogenesis to gliogenesis in the vertebrate CNS are incompletely understood. We identified a family of transcription factors, called NFI genes, which are induced throughout the spinal cord ventricular zone (VZ) concomitantly with the induction of GLAST, an early marker ...

journal_title：Neuron

authors： Deneen B,Ho R,Lukaszewicz A,Hochstim CJ,Gronostajski RM,Anderson DJ

更新日期：2006-12-21 00:00:00

abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...

journal_title：Neuron

authors： Gu Z,Serradj N,Ueno M,Liang M,Li J,Baccei ML,Martin JH,Yoshida Y

更新日期：2017-05-03 00:00:00

abstract：:Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...

journal_title：Neuron

authors： Shah S,Lubeck E,Zhou W,Cai L

更新日期：2016-10-19 00:00:00

abstract：:Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...

journal_title：Neuron

authors： Matthews PM,Hampshire A

更新日期：2016-08-03 00:00:00

abstract：:We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...

journal_title：Neuron

authors： Watanabe T,Raff MC

更新日期：1990-03-01 00:00:00

abstract：:Following alpha-latrotoxin application to cerebellar slices, bursts of miniature IPSCs (mIPSCs) were observed in interneurons of the molecular layer. Within bursts, mIPSCs had homogeneous amplitudes with a narrow Gaussian distribution. Analysis of successive event amplitudes revealed an interaction between consecutive...

journal_title：Neuron

authors： Auger C,Marty A

更新日期：1997-07-01 00:00:00

abstract：:Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal ...

journal_title：Neuron

authors： Hui A,Ellinor PT,Krizanova O,Wang JJ,Diebold RJ,Schwartz A

更新日期：1991-07-01 00:00:00

abstract：:The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...

journal_title：Neuron

authors： Kania A,Jessell TM

更新日期：2003-05-22 00:00:00

abstract：:The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...

journal_title：Neuron

authors： Huang X,Cheng HJ,Tessier-Lavigne M,Jin Y

更新日期：2002-05-16 00:00:00

abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...

journal_title：Neuron

authors： Watabe-Uchida M,Zhu L,Ogawa SK,Vamanrao A,Uchida N

更新日期：2012-06-07 00:00:00

abstract：:GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the expected pharmacological diversity of native receptors and it is unknown whether they contribute to pre- as well as postsynaptic functions. Here, we demonstrate tha...

journal_title：Neuron

authors： Schuler V,Lüscher C,Blanchet C,Klix N,Sansig G,Klebs K,Schmutz M,Heid J,Gentry C,Urban L,Fox A,Spooren W,Jaton AL,Vigouret J,Pozza M,Kelly PH,Mosbacher J,Froestl W,Käslin E,Korn R,Bischoff S,Kaupmann K,van der

更新日期：2001-07-19 00:00:00

abstract：:Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...

journal_title：Neuron

authors： Park CS,Miller C

更新日期：1992-08-01 00:00:00

abstract：:Dopamine is thought to play a critical role in reinforcement learning and goal-directed behavior, but its function in action selection remains largely unknown. Here we demonstrate that nigrostriatal dopamine biases ongoing action selection. When mice were trained to dynamically switch the action selected at different ...

journal_title：Neuron

authors： Howard CD,Li H,Geddes CE,Jin X

更新日期：2017-03-22 00:00:00

abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...

journal_title：Neuron

authors： Sabatini BL,Oertner TG,Svoboda K

更新日期：2002-01-31 00:00:00

abstract：:Circadian clock proteins are modified in many different ways. The best-studied posttranslational modification is phosphorylation, with well-known kinases and phosphatases regulating the function and stability of clock proteins. Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of t...

journal_title：Neuron

authors： Sehgal A

更新日期：2008-01-10 00:00:00

abstract：:The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstr...

journal_title：Neuron

authors： Iascone DM,Li Y,Sümbül U,Doron M,Chen H,Andreu V,Goudy F,Blockus H,Abbott LF,Segev I,Peng H,Polleux F

更新日期：2020-05-20 00:00:00

abstract：:Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...

journal_title：Neuron

authors： Hnasko TS,Chuhma N,Zhang H,Goh GY,Sulzer D,Palmiter RD,Rayport S,Edwards RH

更新日期：2010-03-11 00:00:00

abstract：:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years ...

journal_title：Neuron

authors： Bezanilla F

更新日期：2008-11-06 00:00:00

abstract：:We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...

journal_title：Neuron

authors： Lukaszewicz A,Savatier P,Cortay V,Giroud P,Huissoud C,Berland M,Kennedy H,Dehay C

更新日期：2005-08-04 00:00:00

abstract：:Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation. ...

journal_title：Neuron

authors： Pinheiro EM,Gertler FB

更新日期：2006-09-21 00:00:00

abstract：:Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...

journal_title：Neuron

authors： Fossier P,Baux G,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...

journal_title：Neuron

authors： Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

更新日期：2006-09-21 00:00:00

abstract：:In the CNS, activity of individual neurons has a small but quantifiable relationship to sensory representations and motor outputs. Coactivation of a few 10s to 100s of neurons can code sensory inputs and behavioral task performance within psychophysical limits. However, in a sea of sensory inputs and demand for comple...

journal_title：Neuron

authors： Ainsworth M,Lee S,Cunningham MO,Traub RD,Kopell NJ,Whittington MA

更新日期：2012-08-23 00:00:00

abstract：:In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...

journal_title：Neuron

authors： Otsu Y,Marcaggi P,Feltz A,Isope P,Kollo M,Nusser Z,Mathieu B,Kano M,Tsujita M,Sakimura K,Dieudonné S

更新日期：2014-10-01 00:00:00

abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...

journal_title：Neuron

authors： Sjulson L,Peyrache A,Cumpelik A,Cassataro D,Buzsáki G

更新日期：2018-06-06 00:00:00

abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...

journal_title：Neuron

authors： Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

更新日期：1996-10-01 00:00:00

abstract：:Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...

journal_title：Neuron

authors： Choi KL,Mossman C,Aubé J,Yellen G

更新日期：1993-03-01 00:00:00

abstract：:Human vision adapts to the contrast of patterns by changing its sensitivity, but the origins of this perceptual adaptation have been disputed. In this issue of Neuron, Solomon et al. show that contrast adaptation in the primate arises mostly in the retina for the magnocellular pathway and mostly in the cortex for the ...

journal_title：Neuron

authors： Baccus SA,Meister M

更新日期：2004-04-08 00:00:00