Compartmentalization of acetylcholinesterase mRNA and enzyme at the vertebrate neuromuscular junction.

abstract：:GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...

journal_title：Neuron

authors： Zilberter Y,Kaiser KM,Sakmann B

更新日期：1999-12-01 00:00:00

abstract：:Despite the best available medical treatments, many patients continue to be disabled by neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging and neurophysiology over the last two decades have led to a reinterpretation of some neurologic and psychiatric conditions as primarily diso...

journal_title：Neuron

authors： Lozano AM,Lipsman N

更新日期：2013-02-06 00:00:00

abstract：:Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...

journal_title：Neuron

authors： Hwang HW,Saito Y,Park CY,Blachère NE,Tajima Y,Fak JJ,Zucker-Scharff I,Darnell RB

更新日期：2017-09-13 00:00:00

abstract：:Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...

journal_title：Neuron

authors： Romo R,Hernández A,Zainos A,Brody CD,Lemus L

更新日期：2000-04-01 00:00:00

abstract：:Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...

journal_title：Neuron

authors： Johnson MD

更新日期：1994-02-01 00:00:00

abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...

journal_title：Neuron

authors： Hoover BR,Reed MN,Su J,Penrod RD,Kotilinek LA,Grant MK,Pitstick R,Carlson GA,Lanier LM,Yuan LL,Ashe KH,Liao D

更新日期：2010-12-22 00:00:00

abstract：:Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...

journal_title：Neuron

authors： Vlasits AL,Bos R,Morrie RD,Fortuny C,Flannery JG,Feller MB,Rivlin-Etzion M

更新日期：2014-09-03 00:00:00

abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...

journal_title：Neuron

authors： De Rosa E,Desmond JE,Anderson AK,Pfefferbaum A,Sullivan EV

更新日期：2004-03-04 00:00:00

abstract：:Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (alpha) rhythm. However, how the alpha rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the latera...

journal_title：Neuron

authors： Lorincz ML,Kékesi KA,Juhász G,Crunelli V,Hughes SW

更新日期：2009-09-10 00:00:00

abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

journal_title：Neuron

authors： Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

更新日期：2003-10-30 00:00:00

abstract：:Rostrocaudal polarity of the tectum is first detectable at embryonic day 2 (E2) in the chick by the rostrocaudal gradient of en expression. When ectopic tectum is produced by heterotopic transplantation at E2 in the diencephalon, the gradient of en expression is inverted from the host polarity by environmental influen...

journal_title：Neuron

authors： Itasaki N,Nakamura H

更新日期：1992-04-01 00:00:00

abstract：:Brief bath application of N-methyl-D-aspartate (NMDA) to hippocampal slices produces long-term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age, (2) saturable, (3) induced postsynaptically, (4) reversible, and (5) not associated with a change in paired pulse facilitation. Chemically induced LTD ...

journal_title：Neuron

authors： Lee HK,Kameyama K,Huganir RL,Bear MF

更新日期：1998-11-01 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to u...

journal_title：Neuron

authors： Biederer T,Kaeser PS,Blanpied TA

更新日期：2017-11-01 00:00:00

abstract：:Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...

journal_title：Neuron

authors： Ganguli S,Latham P

更新日期：2009-02-26 00:00:00

abstract：:We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for ...

journal_title：Neuron

authors： Taupin P,Ray J,Fischer WH,Suhr ST,Hakansson K,Grubb A,Gage FH

更新日期：2000-11-01 00:00:00

abstract：:Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many studies have examined the role of small G proteins, particularly the Ras family of G proteins, in memory formation. Once thought to be primar...

journal_title：Neuron

authors： Ye X,Carew TJ

更新日期：2010-11-04 00:00:00

abstract：:Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....

journal_title：Neuron

authors： Jia Y,Zhao Y,Kusakizako T,Wang Y,Pan C,Zhang Y,Nureki O,Hattori M,Yan Z

更新日期：2020-01-22 00:00:00

abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

journal_title：Neuron

authors： Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

更新日期：2018-04-04 00:00:00

abstract：:Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...

journal_title：Neuron

authors： Song I,Kamboj S,Xia J,Dong H,Liao D,Huganir RL

更新日期：1998-08-01 00:00:00

abstract：:Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion ...

journal_title：Neuron

authors： Tombola F,Pathak MM,Isacoff EY

更新日期：2005-12-08 00:00:00

abstract：:Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...

journal_title：Neuron

authors： Zhao Q,Wu K,Geng J,Chi S,Wang Y,Zhi P,Zhang M,Xiao B

更新日期：2016-03-16 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...

journal_title：Neuron

authors： Lo L,Anderson DJ

更新日期：2011-12-22 00:00:00

abstract：:Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...

journal_title：Neuron

authors： Wadiche JI,Amara SG,Kavanaugh MP

更新日期：1995-09-01 00:00:00

abstract：:We have examined the influence of retinal innervation on the development of target neurons in the first optic ganglion, the lamina, of D. melanogaster. Mitotically active lamina precursor cells (LPCs), which normally produce lamina neurons, are absent in mutants that lack retinal innervation, while other proliferative...

journal_title：Neuron

authors： Selleck SB,Steller H

更新日期：1991-01-01 00:00:00

abstract：:Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of inactivation in Shaker potassium channels. N-type inactivation can occur as rapidly as a few milliseconds and has been ...

journal_title：Neuron

authors： Hoshi T,Zagotta WN,Aldrich RW

更新日期：1991-10-01 00:00:00

abstract：:Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...

journal_title：Neuron

authors： Ehlers MD

更新日期：2000-11-01 00:00:00

abstract：:The intraparietal cortex is involved in the control of visually guided actions, like reach-to-grasp movements, which require extracting the 3D shape and position of objects from 2D retinal images. Using fMRI in behaving monkeys, we investigated the role of the intraparietal cortex in processing stereoscopic informatio...

journal_title：Neuron

authors： Durand JB,Nelissen K,Joly O,Wardak C,Todd JT,Norman JF,Janssen P,Vanduffel W,Orban GA

更新日期：2007-08-02 00:00:00

abstract：:Cortical development depends upon tightly controlled cell fate and cell survival decisions that generate a functional neuronal population, but the coordination of these two processes is poorly understood. Here we show that conditional removal of a key apical complex protein, Pals1, causes premature withdrawal from the...

journal_title：Neuron

authors： Kim S,Lehtinen MK,Sessa A,Zappaterra MW,Cho SH,Gonzalez D,Boggan B,Austin CA,Wijnholds J,Gambello MJ,Malicki J,LaMantia AS,Broccoli V,Walsh CA

更新日期：2010-04-15 00:00:00