Abstract：
:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We then depolarized and hyperpolarized each neuron type and quantified fly behavioral responses to a diverse set of motion stimuli. We found that only a small number of lamina output neurons are essential for motion detection, while most neurons serve to sculpt and enhance these feedforward pathways. Two classes of feedback neurons (C2 and C3), and lamina output neurons (L2 and L4), are required for normal detection of directional motion stimuli. Our results reveal a prominent role for feedback and lateral interactions in motion processing and demonstrate that motion-dependent behaviors rely on contributions from nearly all lamina neuron classes.
journal_name
Neuronjournal_title
Neuronauthors
Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MBdoi
10.1016/j.neuron.2013.05.024subject
Has Abstractpub_date
2013-07-10 00:00:00pages
128-40issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00444-3journal_volume
79pub_type
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