当前位置： SCI文献检索 > NEURON期刊下所有文献 > The human basal forebrain integrates the old and the new.

The human basal forebrain integrates the old and the new.

Abstract：

:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI depends on cholinergic modulation from basal forebrain (BF). Whether the BF promotes PI resolution in humans is unknown. Here, we adapted a PI paradigm from animal studies for use in a functional MRI experiment. During PI resolution, neurologically intact subjects recruited a BF network that included afferent anterior and posterior cortical sites associated with efficient memory acquisition and perceptual processing. Despite normal performance, nonamnesic patients with alcoholism, which is known to disrupt BF function, did not activate a BF network but instead invoked anterior cortical sites traditionally associated with executive function. These results provide evidence for parallel neural systems, each with the potential to resolve interference in the face of competing information.

journal_name

Neuron

journal_title

Neuron

authors

De Rosa E,Desmond JE,Anderson AK,Pfefferbaum A,Sullivan EV

doi

10.1016/s0896-6273(04)00080-7

subject

Has Abstract

pub_date

2004-03-04 00:00:00

pages

825-37

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896627304000807

journal_volume

41

pub_type

杂志文章

相关文献

NEURON文献大全
  • Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells.

    abstract：:We have investigated the specification of noradrenergic neurotransmitter identity in neural crest stem cells (NCSCs). Retroviral expression of both wild-type and dominant-negative forms of the paired homeodomain transcription factor Phox2a indicates a crucial and direct role for this protein (and/or the closely relate...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)80729-1

    authors： Lo L,Morin X,Brunet JF,Anderson DJ

    更新日期：1999-04-01 00:00:00

  • Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.

    abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2010.06.002

    authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

    更新日期：2010-07-15 00:00:00

  • Discrete Stepping and Nonlinear Ramping Dynamics Underlie Spiking Responses of LIP Neurons during Decision-Making.

    abstract：:Neurons in LIP exhibit ramping trial-averaged responses during decision-making. Recent work sparked debate over whether single-trial LIP spike trains are better described by discrete "stepping" or continuous "ramping" dynamics. We extended latent dynamical spike train models and used Bayesian model comparison to addre...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2019.04.031

    authors： Zoltowski DM,Latimer KW,Yates JL,Huk AC,Pillow JW

    更新日期：2019-06-19 00:00:00

  • The neurotransmitter cycle and quantal size.

    abstract：:Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2007.09.001

    authors： Edwards RH

    更新日期：2007-09-20 00:00:00

  • Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.

    abstract：:The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarized transport; however, the sorting mechanism to exclude dendritic cargo from the axon is unclear. We show that the dynein regulator...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.01.022

    authors： Kuijpers M,van de Willige D,Freal A,Chazeau A,Franker MA,Hofenk J,Rodrigues RJ,Kapitein LC,Akhmanova A,Jaarsma D,Hoogenraad CC

    更新日期：2016-02-03 00:00:00

  • Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape.

    abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2007.10.031

    authors： Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AW

    更新日期：2007-12-20 00:00:00

  • Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease.

    abstract：:Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and other physiological responses. They are encoded by ten genes, which generate three voltage-gated calcium channel subfamilies: CaV1; CaV2;...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2018.03.017

    authors： Nanou E,Catterall WA

    更新日期：2018-05-02 00:00:00

  • Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex.

    abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)00008-8

    authors： Feldman DE

    更新日期：2000-07-01 00:00:00

  • PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

    abstract：:As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2006.10.032

    authors： Yoshida Y,Han B,Mendelsohn M,Jessell TM

    更新日期：2006-12-07 00:00:00

  • Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.

    abstract：:Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse chan...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.11.016

    authors： Wang GX,Smith SJ,Mourrain P

    更新日期：2014-12-17 00:00:00

  • Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

    abstract：:Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)80760-6

    authors： Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

    更新日期：1999-05-01 00:00:00

  • Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in culture.

    abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(94)90051-5

    authors： Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Y

    更新日期：1994-11-01 00:00:00

  • Light-dependent translocation of visual arrestin regulated by the NINAC myosin III.

    abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2004.06.014

    authors： Lee SJ,Montell C

    更新日期：2004-07-08 00:00:00

  • Temporal and spatial modulation of a cytoskeletal antigen during peripheral axonal pathfinding.

    abstract：:A neuron-specific cytoskeletal antigen (5E10), whose expression pattern during initial motoneuron outgrowth into the chick limb suggests that it is playing a role in axon guidance, is described. This antigen, which was shown to be a phosphorylated epitope, probably of the intermediate weight neurofilament protein (NF-...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(92)90296-p

    authors： Landmesser L,Swain S

    更新日期：1992-02-01 00:00:00

  • How quickly can GABAA receptors open?

    abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(94)90152-x

    authors： Maconochie DJ,Zempel JM,Steinbach JH

    更新日期：1994-01-01 00:00:00

  • Dysfunction of cortical dendritic integration in neuropathic pain reversed by serotoninergic neuromodulation.

    abstract：:Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain une...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2015.03.003

    authors： Santello M,Nevian T

    更新日期：2015-04-08 00:00:00

  • RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice.

    abstract：:The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(03)00034-5

    authors： Miyashiro KY,Beckel-Mitchener A,Purk TP,Becker KG,Barret T,Liu L,Carbonetto S,Weiler IJ,Greenough WT,Eberwine J

    更新日期：2003-02-06 00:00:00

  • Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

    abstract：:To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(94)90458-8

    authors： Iwatsubo T,Odaka A,Suzuki N,Mizusawa H,Nukina N,Ihara Y

    更新日期：1994-07-01 00:00:00

  • The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration.

    abstract：:Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2015.10.004

    authors： Isaacman-Beck J,Schneider V,Franzini-Armstrong C,Granato M

    更新日期：2015-11-18 00:00:00

  • Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.

    abstract：:The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(01)00236-7

    authors： Jiang Y,Pico A,Cadene M,Chait BT,MacKinnon R

    更新日期：2001-03-01 00:00:00

  • Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs.

    abstract：:Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(01)80051-9

    authors： Tse FW,Tse A,Hille B,Horstmann H,Almers W

    更新日期：1997-01-01 00:00:00

  • Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly.

    abstract：:Lissencephaly (LIS), denoting a "smooth brain," is characterized by the absence of normal cerebral convolutions with abnormalities of cortical thickness. Pathogenic variants in over 20 genes are associated with LIS. The majority of posterior predominant LIS is caused by pathogenic variants in LIS1 (also known as PAFAH...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2020.01.027

    authors： Tsai MH,Muir AM,Wang WJ,Kang YN,Yang KC,Chao NH,Wu MF,Chang YC,Porter BE,Jansen LA,Sebire G,Deconinck N,Fan WL,Su SC,Chung WH,Almanza Fuerte EP,Mehaffey MG,University of Washington Center for Mendelian Genomics.,Ng CC

    更新日期：2020-04-22 00:00:00

  • L-myc and N-myc influence lineage determination in the central nervous system.

    abstract：:The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of their expression in single neuroepithelial cells revealed that neural precursors not yet committed to the glial or the neuronal lineage expressed both genes, but after lineage commitment they e...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(92)90079-s

    authors： Bernard O,Drago J,Sheng H

    更新日期：1992-12-01 00:00:00

  • Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling.

    abstract：:In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2019.04.019

    authors： Panayotis N,Fainzilber M

    更新日期：2019-05-08 00:00:00

  • The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes.

    abstract：:von Recklinghausen's neurofibromatosis (NF1) is a common inherited human disease. The events leading to patient symptoms from inheritance of a defective NF1 gene are unknown. Since knowledge of the distribution of the normal NF1 gene product should improve understanding of the pathogenesis of the disease, we raised an...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(92)90270-n

    authors： Daston MM,Scrable H,Nordlund M,Sturbaum AK,Nissen LM,Ratner N

    更新日期：1992-03-01 00:00:00

  • Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons.

    abstract：:Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.04.003

    authors： Robinson NTM,Priestley JB,Rueckemann JW,Garcia AD,Smeglin VA,Marino FA,Eichenbaum H

    更新日期：2017-05-03 00:00:00

  • Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo.

    abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(03)00682-2

    authors： Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

    更新日期：2003-10-30 00:00:00

  • Cocaine Place Conditioning Strengthens Location-Specific Hippocampal Coupling to the Nucleus Accumbens.

    abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2018.04.015

    authors： Sjulson L,Peyrache A,Cumpelik A,Cassataro D,Buzsáki G

    更新日期：2018-06-06 00:00:00

  • Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2(+)-independent activity.

    abstract：:After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(88)90109-2

    authors： Miller SG,Patton BL,Kennedy MB

    更新日期：1988-09-01 00:00:00

  • Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo.

    abstract：:Biochemical studies suggest that syntaxin 1A participates in multiple protein-protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to eliminate specific syntaxin binding interactions and demonstrate that Drosophi...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(00)80811-9

    authors： Wu MN,Fergestad T,Lloyd TE,He Y,Broadie K,Bellen HJ

    更新日期：1999-07-01 00:00:00