Abstract:
:Neurons in LIP exhibit ramping trial-averaged responses during decision-making. Recent work sparked debate over whether single-trial LIP spike trains are better described by discrete "stepping" or continuous "ramping" dynamics. We extended latent dynamical spike train models and used Bayesian model comparison to address this controversy. First, we incorporated non-Poisson spiking into both models and found that more neurons were better described by stepping than ramping, even when conditioned on evidence or choice. Second, we extended the ramping model to include a non-zero baseline and compressive output nonlinearity. This model accounted for roughly as many neurons as the stepping model. However, latent dynamics inferred under this model exhibited high diffusion variance for many neurons, softening the distinction between continuous and discrete dynamics. Results generalized to additional datasets, demonstrating that substantial fractions of neurons are well described by either stepping or nonlinear ramping, which may be less categorically distinct than the original labels implied.
journal_name
Neuronjournal_title
Neuronauthors
Zoltowski DM,Latimer KW,Yates JL,Huk AC,Pillow JWdoi
10.1016/j.neuron.2019.04.031subject
Has Abstractpub_date
2019-06-19 00:00:00pages
1249-1258.e10issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(19)30388-5journal_volume
102pub_type
杂志文章相关文献
NEURON文献大全abstract::According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.09.040
更新日期:2009-11-12 00:00:00
abstract::Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.021
更新日期:2016-08-03 00:00:00
abstract::Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical pro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.01.023
更新日期:2011-03-10 00:00:00
abstract::Adaptation or gain control allows sensory neurons to encode diverse stimuli using a limited range of output signals. Rod vision exemplifies a general challenge facing adaptational mechanisms-balancing the benefits of averaging to create a reliable signal for adaptation with the need to adapt rapidly and locally. The s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.01.031
更新日期:2008-03-27 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00394-4
更新日期:2001-08-30 00:00:00
abstract::Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin. However, how signal is transduced from agrin to MuSK remains unclear. We report that LRP4, a low-density lipoprotein receptor (LDLR)-related protein, is expre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.10.006
更新日期:2008-10-23 00:00:00
abstract::Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.02.003
更新日期:2010-02-25 00:00:00
abstract::Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(03)00681-0
更新日期:2003-10-30 00:00:00
abstract::Axon pruning by degeneration remodels exuberant axonal connections and is widely required for the development of proper circuitry in the nervous system from insects to mammals. Developmental axon degeneration morphologically resembles injury-induced Wallerian degeneration, suggesting similar underlying mechanisms. As ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.05.013
更新日期:2006-06-15 00:00:00
abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.035
更新日期:2019-04-03 00:00:00
abstract::There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.06.041
更新日期:2015-07-15 00:00:00
abstract::Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80051-9
更新日期:1997-01-01 00:00:00
abstract::Neural crest cells of vertebrate embryos produce neurons, glia, pigment cells, and connective tissue in vivo and in vitro. To test the developmental potential of apparently undifferentiated crest cells, we have used the monoclonal antibody A2B5, which recognizes a cell surface glycolipid characteristic of neurons, to ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90106-7
更新日期:1988-09-01 00:00:00
abstract::In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic hom...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.09.008
更新日期:2009-09-24 00:00:00
abstract::Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging g...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.08.039
更新日期:2018-10-10 00:00:00
abstract::Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.05.011
更新日期:2014-05-21 00:00:00
abstract::Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.009
更新日期:2011-04-28 00:00:00
abstract::GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90338-g
更新日期:1990-12-01 00:00:00
abstract::Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.03.003
更新日期:2018-04-04 00:00:00
abstract::We have used biochemical and immunocytochemical techniques to investigate the possible involvement of membrane cytoskeletal elements such as alpha-actinin, calspectin (brain spectrin or fodrin), and actin in growth cone activities. During NGF-induced differentiation of PC12 cells, alpha-actinin increased in associatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90255-9
更新日期:1989-09-01 00:00:00
abstract::The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.04.019
更新日期:2006-05-18 00:00:00
abstract::By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.04.008
更新日期:2016-04-20 00:00:00
abstract::S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.05.005
更新日期:2013-05-22 00:00:00
abstract::Amphetamine (AMPH) releases monoamines, transiently stimulates locomotion, and inhibits feeding. Using a genetic approach, we show that mice lacking dopamine (DA-deficient, or DD, mice) are resistant to the hypophagic effects of a moderate dose of AMPH (2 microg/g) but manifest normal AMPH-induced hypophagia after res...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.10.009
更新日期:2004-10-28 00:00:00
abstract::Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in surrounding neuropil. Here, we describe two strategies for using the ribosome to restrict the expression of f...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.05.005
更新日期:2020-08-05 00:00:00
abstract::We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00410-x
更新日期:2001-09-13 00:00:00
abstract::Despite the fact that strong trial-to-trial correlated variability in responses has been reported in many cortical areas, recent evidence suggests that neuronal correlations are much lower than previously thought. Here, we used multicontact laminar probes to revisit the issue of correlated variability in primary visua...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.029
更新日期:2012-11-08 00:00:00
abstract::Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.09.019
更新日期:2020-12-23 00:00:00
abstract::In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.06.018
更新日期:2010-07-29 00:00:00
abstract::Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.06.009
更新日期:2004-06-24 00:00:00