Abstract：
:A neuron-specific cytoskeletal antigen (5E10), whose expression pattern during initial motoneuron outgrowth into the chick limb suggests that it is playing a role in axon guidance, is described. This antigen, which was shown to be a phosphorylated epitope, probably of the intermediate weight neurofilament protein (NF-M), exhibits a highly stereotyped and spatially heterogeneous pattern of expression. The point of onset of expression, which was abrupt and occurred in the distal axon and base of the growth cone, differed between groups of neurons that projected to different targets. Specifically, expression occurred from positions where previous perturbation experiments suggested that the axons in question would begin responding to specific guidance cues, and it remained high along the axon from this point to the target. Expression of this antigen could also be induced in cultured motoneurons by activating several second messenger systems.
journal_name
Neuronjournal_title
Neuronauthors
Landmesser L,Swain Sdoi
10.1016/0896-6273(92)90296-psubject
Has Abstractpub_date
1992-02-01 00:00:00pages
291-305issue
2eissn
0896-6273issn
1097-4199pii
0896-6273(92)90296-Pjournal_volume
8pub_type
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