Abstract:
:We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a reduced G1 phase, and a higher rate of cell cycle reentry than area 18 precursors; (2) area 17 and area 18 precursors show contrasting and specific levels of expression of cyclin E (high in area 17, low in area 18) and p27Kip1 (low in area 17, high in area 18); (3) ex vivo up- and downmodulation of cyclin E and p27Kip1 show that both regulators influence cell cycle kinetics by modifying rates of cell cycle progression and cell cycle reentry; (4) modeling the areal differences in cell cycle parameters suggests that they contribute to areal differences in numbers of precursors and neuron production.
journal_name
Neuronjournal_title
Neuronauthors
Lukaszewicz A,Savatier P,Cortay V,Giroud P,Huissoud C,Berland M,Kennedy H,Dehay Cdoi
10.1016/j.neuron.2005.06.032subject
Has Abstractpub_date
2005-08-04 00:00:00pages
353-64issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00566-0journal_volume
47pub_type
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