Abstract:
:Phosphatidylinositol 3-kinase (PI3K)-dependent phosphoinositide signaling has been implicated in diverse cellular systems coupled to receptors for many different ligands, but the extent to which it functions in sensory transduction is yet to be determined. We now report that blocking PI3K activity increases odorant-evoked, cyclic nucleotide-dependent elevation of [Ca(2+)](i) in acutely dissociated rat olfactory receptor neurons and does so in an odorant-specific manner. These findings imply that 3-phosphoinositide signaling acts in vertebrate olfactory transduction to inhibit cyclic nucleotide-dependent excitation of the cells and that the interaction of the two signaling pathways is important in odorant coding, indicating that 3-phosphoinositide signaling can play a role in sensory transduction.
journal_name
Neuronjournal_title
Neuronauthors
Spehr M,Wetzel CH,Hatt H,Ache BWdoi
10.1016/s0896-6273(02)00610-4subject
Has Abstractpub_date
2002-02-28 00:00:00pages
731-9issue
5eissn
0896-6273issn
1097-4199pii
S0896627302006104journal_volume
33pub_type
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