Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons.

Abstract:

:The identification of surface proteins restricted to subsets of embryonic axons and growth cones may provide information on the mechanisms underlying axon fasciculation and pathway selection in the vertebrate nervous system. We describe here the characterization of a 135 kd cell surface glycoprotein, TAG-1, that is expressed transiently on subsets of embryonic spinal cord axons and growth cones. TAG-1 is immunochemically distinct from the cell adhesion molecules N-CAM and L1 (NILE) and is expressed on commissural and motor neurons over the period of initial axon extension. Moreover, TAG-1 and L1 appear to be segregated on different segments of the same embryonic spinal axons. These observations provide evidence that axonal guidance and pathway selection in vertebrates may be regulated in part by the transient and selective expression of distinct surface glycoproteins on subsets of developing neurons.

journal_name

Neuron

journal_title

Neuron

authors

Dodd J,Morton SB,Karagogeos D,Yamamoto M,Jessell TM

doi

10.1016/0896-6273(88)90194-8

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

105-16

issue

2

eissn

0896-6273

issn

1097-4199

pii

0896-6273(88)90194-8

journal_volume

1

pub_type

杂志文章

相关文献

NEURON文献大全
  • Top-down coordination of local cortical state during selective attention.

    abstract::Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.12.013

    authors: van Kempen J,Gieselmann MA,Boyd M,Steinmetz NA,Moore T,Engel TA,Thiele A

    更新日期:2020-12-30 00:00:00

  • Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding.

    abstract::Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.03.028

    authors: Vinck M,Batista-Brito R,Knoblich U,Cardin JA

    更新日期:2015-05-06 00:00:00

  • Multiple calcium-dependent processes related to secretion in bovine chromaffin cells.

    abstract::We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90238-m

    authors: Neher E,Zucker RS

    更新日期:1993-01-01 00:00:00

  • A Central Move for CB2 Receptors.

    abstract::The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.neuron.2016.05.012

    authors: Quraishi SA,Paladini CA

    更新日期:2016-05-18 00:00:00

  • Blockade of ion channel expression in Xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs.

    abstract::Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90153-5

    authors: Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

    更新日期:1988-12-01 00:00:00

  • Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina.

    abstract::We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(90)90058-n

    authors: Watanabe T,Raff MC

    更新日期:1990-03-01 00:00:00

  • Developmental regulation of neuronal K+ channels by target-derived TGF beta in vivo and in vitro.

    abstract::The functional expression of Ca2+-activated K+ channels (KCa) in developing chick ciliary ganglion (CG) neurons requires interactions with target tissues and preganglionic innervation. Here, we show that the stimulatory effects of target tissues are mediated by an isoform of TGFbeta. Exposure of cultured CG neurons to...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80622-4

    authors: Cameron JS,Lhuillier L,Subramony P,Dryer SE

    更新日期:1998-11-01 00:00:00

  • Oscillatory substrates of fear and safety.

    abstract::Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2014.08.014

    authors: Bocchio M,Capogna M

    更新日期:2014-08-20 00:00:00

  • Linx mediates interaxonal interactions and formation of the internal capsule.

    abstract::During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.05.020

    authors: Mandai K,Reimert DV,Ginty DD

    更新日期:2014-07-02 00:00:00

  • Structure and assembly mechanism for heteromeric kainate receptors.

    abstract::Native glutamate receptor ion channels are tetrameric assemblies containing two or more different subunits. NMDA receptors are obligate heteromers formed by coassembly of two or three divergent gene families. While some AMPA and kainate receptors can form functional homomeric ion channels, the KA1 and KA2 subunits are...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.05.038

    authors: Kumar J,Schuck P,Mayer ML

    更新日期:2011-07-28 00:00:00

  • Triangulating the neural, psychological, and economic bases of guilt aversion.

    abstract:VIDEO ABSTRACT:Why do people often choose to cooperate when they can better serve their interests by acting selfishly? One potential mechanism is that the anticipation of guilt can motivate cooperative behavior. We utilize a formal model of this process in conjunction with fMRI to identify brain regions that mediate co...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.02.056

    authors: Chang LJ,Smith A,Dufwenberg M,Sanfey AG

    更新日期:2011-05-12 00:00:00

  • Growing Myelin around Regenerated Axons after CNS Injury.

    abstract::In this issue of Neuron, Wang et al. demonstrate that both cell-intrinsic and -extrinsic factors restrict the myelination of newly regenerated axons. Pharmalogical targeting of GPR17 signaling in oligodendrocyte precursor cells (OPCs) and microglial inhibition of oligodendrocyte maturation together promote robust myel...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2020.10.033

    authors: Hilton BJ,Bradke F

    更新日期:2020-12-09 00:00:00

  • The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211.

    abstract::Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.12.057

    authors: Petersen SC,Luo R,Liebscher I,Giera S,Jeong SJ,Mogha A,Ghidinelli M,Feltri ML,Schöneberg T,Piao X,Monk KR

    更新日期:2015-02-18 00:00:00

  • Sensory deprivation unmasks a PKA-dependent synaptic plasticity mechanism that operates in parallel with CaMKII.

    abstract::Calcium/calmodulin kinase II (CaMKII) is required for LTP and experience-dependent potentiation in the barrel cortex. Here, we find that whisker deprivation increases LTP in the layer IV to II/III pathway and that PKA antagonists block the additional LTP. No LTP was seen in undeprived CaMKII-T286A mice, but whisker de...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.10.018

    authors: Hardingham N,Wright N,Dachtler J,Fox K

    更新日期:2008-12-10 00:00:00

  • Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

    abstract::NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.01.035

    authors: Hansen KB,Ogden KK,Yuan H,Traynelis SF

    更新日期:2014-03-05 00:00:00

  • Immunological characterization of K+ channel components from the Shaker locus and differential distribution of splicing variants in Drosophila.

    abstract::Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocy...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(90)90448-o

    authors: Schwarz TL,Papazian DM,Carretto RC,Jan YN,Jan LY

    更新日期:1990-01-01 00:00:00

  • Von Economo neurons in the anterior insula of the macaque monkey.

    abstract::The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.03.003

    authors: Evrard HC,Forro T,Logothetis NK

    更新日期:2012-05-10 00:00:00

  • A role for Abl in Notch signaling.

    abstract::Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)81007-7

    authors: Giniger E

    更新日期:1998-04-01 00:00:00

  • The force be with you: a mechanoreceptor channel in proprioception and touch.

    abstract::The TRPN1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in nematodes. In this issue of Neuron, two papers present evidence that TRPN1 is also required for proprioception in fruit fly larvae and that it is a bona fide mechanoreceptor channel for nematode feedin...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2010.07.022

    authors: Wilson RI,Corey DP

    更新日期:2010-08-12 00:00:00

  • Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia.

    abstract::We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cas...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.04.022

    authors: Pocklington AJ,Rees E,Walters JT,Han J,Kavanagh DH,Chambert KD,Holmans P,Moran JL,McCarroll SA,Kirov G,O'Donovan MC,Owen MJ

    更新日期:2015-06-03 00:00:00

  • Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2(+)-independent activity.

    abstract::After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90109-2

    authors: Miller SG,Patton BL,Kennedy MB

    更新日期:1988-09-01 00:00:00

  • Together at last: bHLH and LIM-HD regulators cooperate to specify motor neurons.

    abstract::bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between th...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s0896-6273(03)00329-5

    authors: Allan DW,Thor S

    更新日期:2003-06-05 00:00:00

  • The Biology of Huntingtin.

    abstract::Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2016.02.003

    authors: Saudou F,Humbert S

    更新日期:2016-03-02 00:00:00

  • aex-3 encodes a novel regulator of presynaptic activity in C. elegans.

    abstract::C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80302-5

    authors: Iwasaki K,Staunton J,Saifee O,Nonet M,Thomas JH

    更新日期:1997-04-01 00:00:00

  • JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.

    abstract::Autism spectrum disorder (ASD) is a heritable, common neurodevelopmental disorder with diverse genetic causes. Several studies have implicated protein synthesis as one among several of its potential convergent mechanisms. We originally identified Janus kinase and microtubule-interacting protein 1 (JAKMIP1) as differen...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.10.031

    authors: Berg JM,Lee C,Chen L,Galvan L,Cepeda C,Chen JY,Peñagarikano O,Stein JL,Li A,Oguro-Ando A,Miller JA,Vashisht AA,Starks ME,Kite EP,Tam E,Gdalyahu A,Al-Sharif NB,Burkett ZD,White SA,Fears SC,Levine MS,Wohlschlegel

    更新日期:2015-12-16 00:00:00

  • Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes.

    abstract::The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80850-8

    authors: Davis AF,Bai J,Fasshauer D,Wolowick MJ,Lewis JL,Chapman ER

    更新日期:1999-10-01 00:00:00

  • A genetic push to understand motion detection.

    abstract::Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2011.06.005

    authors: Gabbiani F,Jones PW

    更新日期:2011-06-23 00:00:00

  • Transient slow gamma synchrony underlies hippocampal memory replay.

    abstract::The replay of previously stored memories during hippocampal sharp wave ripples (SWRs) is thought to support both memory retrieval and consolidation in distributed hippocampal-neocortical circuits. Replay events consist of precisely timed sequences of spikes from CA3 and CA1 neurons that are coordinated both within and...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.06.014

    authors: Carr MF,Karlsson MP,Frank LM

    更新日期:2012-08-23 00:00:00

  • The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity.

    abstract::T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.07.036

    authors: García-Caballero A,Gadotti VM,Stemkowski P,Weiss N,Souza IA,Hodgkinson V,Bladen C,Chen L,Hamid J,Pizzoccaro A,Deage M,François A,Bourinet E,Zamponi GW

    更新日期:2014-09-03 00:00:00

  • LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.

    abstract::Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.01.003

    authors: Roppongi RT,Dhume SH,Padmanabhan N,Silwal P,Zahra N,Karimi B,Bomkamp C,Patil CS,Champagne-Jorgensen K,Twilley RE,Zhang P,Jackson MF,Siddiqui TJ

    更新日期:2020-04-08 00:00:00