Unlocking the Potential for Endogenous Repair to Restore Sight.

abstract：:The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...

journal_title：Neuron

authors： Kania A,Jessell TM

更新日期：2003-05-22 00:00:00

abstract：:The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ i...

journal_title：Neuron

authors： Salzer JL

更新日期：2003-10-09 00:00:00

abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...

journal_title：Neuron

authors： Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

更新日期：2014-07-02 00:00:00

abstract：:Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosph...

journal_title：Neuron

authors： Cohen S,Gabel HW,Hemberg M,Hutchinson AN,Sadacca LA,Ebert DH,Harmin DA,Greenberg RS,Verdine VK,Zhou Z,Wetsel WC,West AE,Greenberg ME

更新日期：2011-10-06 00:00:00

abstract：:Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...

journal_title：Neuron

authors： Korade Z,Mirnics K

更新日期：2014-01-22 00:00:00

abstract：:After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in...

journal_title：Neuron

authors： Kuromi H,Kidokoro Y

更新日期：2002-07-18 00:00:00

abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

journal_title：Neuron

authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

更新日期：2014-09-17 00:00:00

abstract：:Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...

journal_title：Neuron

authors： Young TL,Cepko CL

更新日期：2004-03-25 00:00:00

abstract：:The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events. ...

journal_title：Neuron

authors： Barker PA

更新日期：2009-04-16 00:00:00

abstract：:Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala. ...

journal_title：Neuron

authors： Zheng X,Gandhi SP

更新日期：2016-12-21 00:00:00

abstract：:Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that ...

journal_title：Neuron

authors： Nguyen-Ba-Charvet KT,Chédotal A

更新日期：2006-05-18 00:00:00

abstract：:Adolescence is often described as a period of heightened reactivity to emotions paired with reduced regulatory capacities, a combination suggested to contribute to risk-taking and susceptibility to peer influence during puberty. However, no longitudinal research has definitively linked these behavioral changes to unde...

journal_title：Neuron

authors： Pfeifer JH,Masten CL,Moore WE 3rd,Oswald TM,Mazziotta JC,Iacoboni M,Dapretto M

更新日期：2011-03-10 00:00:00

abstract：:The identification of surface proteins restricted to subsets of embryonic axons and growth cones may provide information on the mechanisms underlying axon fasciculation and pathway selection in the vertebrate nervous system. We describe here the characterization of a 135 kd cell surface glycoprotein, TAG-1, that is ex...

journal_title：Neuron

authors： Dodd J,Morton SB,Karagogeos D,Yamamoto M,Jessell TM

更新日期：1988-04-01 00:00:00

abstract：:After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...

journal_title：Neuron

authors： Miller SG,Patton BL,Kennedy MB

更新日期：1988-09-01 00:00:00

abstract：:Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-rela...

journal_title：Neuron

authors： Bhat MA,Rios JC,Lu Y,Garcia-Fresco GP,Ching W,St Martin M,Li J,Einheber S,Chesler M,Rosenbluth J,Salzer JL,Bellen HJ

更新日期：2001-05-01 00:00:00

abstract：:Incoming stimuli are encoded collectively by populations of cortical neurons, which transmit information by using a neural code thought to be predominantly redundant. Redundant coding is widely believed to reflect a design choice whereby neurons with overlapping receptive fields sample environmental stimuli to convey ...

journal_title：Neuron

authors： Nigam S,Pojoga S,Dragoi V

更新日期：2019-10-23 00:00:00

abstract：:Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells i...

journal_title：Neuron

authors： Wang BS,Sarnaik R,Cang J

更新日期：2010-01-28 00:00:00

abstract：:Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chron...

journal_title：Neuron

authors： Turi GF,Li WK,Chavlis S,Pandi I,O'Hare J,Priestley JB,Grosmark AD,Liao Z,Ladow M,Zhang JF,Zemelman BV,Poirazi P,Losonczy A

更新日期：2019-03-20 00:00:00

abstract：:Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge relat...

journal_title：Neuron

authors： Shichinohe N,Akao T,Kurkin S,Fukushima J,Kaneko CR,Fukushima K

更新日期：2009-06-11 00:00:00

abstract：:The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates...

journal_title：Neuron

authors： Krubitzer L

更新日期：2007-10-25 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...

journal_title：Neuron

authors： Schlag JD,Schlag-Rey M

更新日期：2009-06-11 00:00:00

abstract：:Simultaneous whole-cell recordings were made from the soma and dendrites of cerebellar Purkinje cells in rat brain slices. Sodium action potentials, evoked by either depolarizing current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with inc...

journal_title：Neuron

authors： Stuart G,Häusser M

更新日期：1994-09-01 00:00:00

abstract：:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...

journal_title：Neuron

authors： Tonegawa S,Liu X,Ramirez S,Redondo R

更新日期：2015-09-02 00:00:00

abstract：:The development of GABAergic inhibitory circuits is shaped by neural activity, but the underlying mechanisms are unclear. Here, we demonstrate a novel function of GABA in regulating GABAergic innervation in the adolescent brain, when GABA is mainly known as an inhibitory transmitter. Conditional knockdown of the rate-...

journal_title：Neuron

authors： Chattopadhyaya B,Di Cristo G,Wu CZ,Knott G,Kuhlman S,Fu Y,Palmiter RD,Huang ZJ

更新日期：2007-06-21 00:00:00

abstract：:We have cloned from the receptor epithelium of the chick cochlea a family of alternatively spliced cDNAs derived from cslo, which encodes a Ca2+-activated K+ channel like those shown to help determine the resonant frequency of electrically tuned hair cells. Our results from PCRs using template RNAs from both tonotopic...

journal_title：Neuron

authors： Navaratnam DS,Bell TJ,Tu TD,Cohen EL,Oberholtzer JC

更新日期：1997-11-01 00:00:00

abstract：:The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...

journal_title：Neuron

authors： Simerly R

更新日期：2005-05-19 00:00:00

abstract：:Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-...

journal_title：Neuron

authors： Cowan CA,Yokoyama N,Bianchi LM,Henkemeyer M,Fritzsch B

更新日期：2000-05-01 00:00:00

abstract：:The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...

journal_title：Neuron

authors： Adolphs R

更新日期：2016-06-15 00:00:00

abstract：:The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...

journal_title：Neuron

authors： Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJ

更新日期：2000-05-01 00:00:00