Abstract：
:Simultaneous whole-cell recordings were made from the soma and dendrites of cerebellar Purkinje cells in rat brain slices. Sodium action potentials, evoked by either depolarizing current pulses or synaptic stimulation of parallel or climbing fibers, always occurred first at the soma and decreased in amplitude with increasing distance into the dendrites. Simultaneous somatic and axonal recordings showed that these action potentials were initiated in the axon. Outside-out patches excised from the soma and dendrites revealed that the sodium channel current density decreased with distance from the soma. Consistent with this finding, comparable attenuation was observed for evoked action potentials and simulated action potential waveforms when sodium channels were blocked. These results show that sodium action potentials in cerebellar Purkinje cells are initiated in the axon and then spread passively into the dendritic tree.
journal_name
Neuronjournal_title
Neuronauthors
Stuart G,Häusser Mdoi
10.1016/0896-6273(94)90037-xsubject
Has Abstractpub_date
1994-09-01 00:00:00pages
703-12issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(94)90037-Xjournal_volume
13pub_type
杂志文章相关文献
NEURON文献大全abstract：:Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the gene...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.12.003
更新日期：2012-12-20 00:00:00
abstract：:In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2008.08.015
更新日期：2008-09-11 00:00:00
abstract：:Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00789-x
更新日期：2003-12-18 00:00:00
abstract：:Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2014.05.011
更新日期：2014-05-21 00:00:00
abstract：:Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.04.029
更新日期：2019-07-03 00:00:00
abstract：:Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.036
更新日期：2014-06-18 00:00:00
abstract：:Screens for genes that orchestrate neural circuit formation in mammals have been hindered by practical constraints of germline mutagenesis. To overcome these limitations, we combined RNA-seq with somatic CRISPR mutagenesis to study synapse development in the mouse retina. Here synapses occur between cellular layers, f...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.03.004
更新日期：2018-04-04 00:00:00
abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00465-3
更新日期：2003-08-28 00:00:00
abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2009.06.026
更新日期：2009-08-13 00:00:00
abstract：:As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.032
更新日期：2006-12-07 00:00:00
abstract：:Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.10.029
更新日期：2017-12-06 00:00:00
abstract：:An axon is thought to faithfully conduct action potentials to its terminals. However, many features of the axon and axon terminals, especially at inhibitory synapses, remain unknown. By directly recording from the axon and terminal of a cultured cerebellar Purkinje cell (PC), we demonstrate that low membrane excitabil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.02.013
更新日期：2015-03-18 00:00:00
abstract：:The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unkn...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.08.013
更新日期：2010-10-06 00:00:00
abstract：:Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.12.013
更新日期：2020-12-30 00:00:00
abstract：:Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ri...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.017
更新日期：2017-09-27 00:00:00
abstract：:Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.001
更新日期：2016-04-20 00:00:00
abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.017
更新日期：2016-05-04 00:00:00
abstract：:The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.05.047
更新日期：2011-08-11 00:00:00
abstract：:Several molecules involved in the development of the nervous system have specific binding sites for the glycosaminoglycan (GAG) side chains of proteoglycans. Exogenous GAGs should bind to these sites, competitively inhibit interactions with proteoglycans, and perturb development. GAGs added to the culture medium pertu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90091-q
更新日期：1992-04-01 00:00:00
abstract：:There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2015.06.041
更新日期：2015-07-15 00:00:00
abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(00)80043-4
更新日期：1996-02-01 00:00:00
abstract：:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90040-3
更新日期：1995-08-01 00:00:00
abstract：:Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.12.015
更新日期：2020-03-18 00:00:00
abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.03.029
更新日期：2015-04-08 00:00:00
abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.10.046
更新日期：2018-12-19 00:00:00
abstract：:The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80270-6
更新日期：1997-02-01 00:00:00
abstract：:The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look tow...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.12.023
更新日期：2007-02-01 00:00:00
abstract：:Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90132-8
更新日期：1988-11-01 00:00:00
abstract：:The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90257-0
更新日期：1995-06-01 00:00:00
abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.024
更新日期：2012-01-26 00:00:00
