Building neural choice points for love and war.

Abstract:

:The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of convergence for defensive and reproductive olfactory cues that may function as a gating mechanism for sensory activation of defensive responses over reproduction.

journal_name

Neuron

journal_title

Neuron

authors

Simerly R

doi

10.1016/j.neuron.2005.05.001

subject

Has Abstract

pub_date

2005-05-19 00:00:00

pages

525-6

issue

4

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(05)00396-X

journal_volume

46

pub_type

评论,杂志文章

相关文献

NEURON文献大全
  • Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

    abstract::The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.06.017

    authors: Na Y,Park S,Lee C,Kim DK,Park JM,Sockanathan S,Huganir RL,Worley PF

    更新日期:2016-08-03 00:00:00

  • Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking.

    abstract::Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of contex...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.03.033

    authors: Gibson GD,Prasad AA,Jean-Richard-Dit-Bressel P,Yau JOY,Millan EZ,Liu Y,Campbell EJ,Lim J,Marchant NJ,Power JM,Killcross S,Lawrence AJ,McNally GP

    更新日期:2018-05-02 00:00:00

  • Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

    abstract::Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.10.032

    authors: Taniguchi M,Carreira MB,Smith LN,Zirlin BC,Neve RL,Cowan CW

    更新日期:2012-01-12 00:00:00

  • Off on a tangent: thalamocortical axons traverse a permissive corridor across the basal telencephalon.

    abstract::The forebrain is one of most complex cellular structures known. Two phenomena that enable this complexity are tangential migrations that mix neurons from distinct progenitor fields, and axon guidance across intervening, noninnervated fields. A new paper in Cell by López-Bendito et al. has discovered the convergence of...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2006.04.001

    authors: Maroof AM,Anderson SA

    更新日期:2006-04-20 00:00:00

  • Four GABAergic interneurons impose feeding restraint in Drosophila.

    abstract::Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.05.006

    authors: Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

    更新日期:2014-07-02 00:00:00

  • Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.

    abstract::The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hypera...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.05.015

    authors: Zhang X,Li L,McNaughton PA

    更新日期:2008-08-14 00:00:00

  • Differential distribution of Ca2+-activated K+ channel splice variants among hair cells along the tonotopic axis of the chick cochlea.

    abstract::We have cloned from the receptor epithelium of the chick cochlea a family of alternatively spliced cDNAs derived from cslo, which encodes a Ca2+-activated K+ channel like those shown to help determine the resonant frequency of electrically tuned hair cells. Our results from PCRs using template RNAs from both tonotopic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80398-0

    authors: Navaratnam DS,Bell TJ,Tu TD,Cohen EL,Oberholtzer JC

    更新日期:1997-11-01 00:00:00

  • Three hundred million years of attentional selection.

    abstract::In this issue of Neuron, Winkowski and Knudsen reveal striking parallels between the attentional systems of the barn owl and the rhesus macaque. The observation of close similarities between the attentional systems of such distantly related organisms strongly suggest that key computational principles are at work. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.neuron.2008.11.006

    authors: Reynolds J

    更新日期:2008-11-26 00:00:00

  • Learning without performance in PKC-deficient Drosophila.

    abstract::The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80270-6

    authors: Kane NS,Robichon A,Dickinson JA,Greenspan RJ

    更新日期:1997-02-01 00:00:00

  • Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output.

    abstract::The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(95)90073-x

    authors: Murphy TH,Baraban JM,Wier WG

    更新日期:1995-07-01 00:00:00

  • Hooked on the D3 receptor: CaMKII's new addiction.

    abstract::The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.01.025

    authors: Hell JW

    更新日期:2009-02-12 00:00:00

  • Thalamic Retrieval of Opioid Memories.

    abstract::Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2020.09.006

    authors: Pribiag H,Lim BK

    更新日期:2020-09-23 00:00:00

  • Multiple calcium-dependent processes related to secretion in bovine chromaffin cells.

    abstract::We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90238-m

    authors: Neher E,Zucker RS

    更新日期:1993-01-01 00:00:00

  • Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.

    abstract::During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00586-4

    authors: Plump AS,Erskine L,Sabatier C,Brose K,Epstein CJ,Goodman CS,Mason CA,Tessier-Lavigne M

    更新日期:2002-01-17 00:00:00

  • Keeping an eye on cortical states.

    abstract::Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2014.10.005

    authors: Poulet JF

    更新日期:2014-10-22 00:00:00

  • Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.

    abstract::In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wirele...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.12.031

    authors: Shin G,Gomez AM,Al-Hasani R,Jeong YR,Kim J,Xie Z,Banks A,Lee SM,Han SY,Yoo CJ,Lee JL,Lee SH,Kurniawan J,Tureb J,Guo Z,Yoon J,Park SI,Bang SY,Nam Y,Walicki MC,Samineni VK,Mickle AD,Lee K,Heo SY,McCall JG,

    更新日期:2017-02-08 00:00:00

  • Spatial segregation of adaptation and predictive sensitization in retinal ganglion cells.

    abstract::Sensory systems change their sensitivity based on recent stimuli to adjust their response range to the range of inputs and to predict future sensory input. Here, we report the presence of retinal ganglion cells that have antagonistic plasticity, showing central adaptation and peripheral sensitization. Ganglion cell re...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.06.011

    authors: Kastner DB,Baccus SA

    更新日期:2013-08-07 00:00:00

  • Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.

    abstract::Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00179-9

    authors: Tanigaki K,Nogaki F,Takahashi J,Tashiro K,Kurooka H,Honjo T

    更新日期:2001-01-01 00:00:00

  • RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice.

    abstract::The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00034-5

    authors: Miyashiro KY,Beckel-Mitchener A,Purk TP,Becker KG,Barret T,Liu L,Carbonetto S,Weiler IJ,Greenough WT,Eberwine J

    更新日期:2003-02-06 00:00:00

  • Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.

    abstract::Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.04.029

    authors: Petzold GC,Albeanu DF,Sato TF,Murthy VN

    更新日期:2008-06-26 00:00:00

  • Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording.

    abstract::An axon is thought to faithfully conduct action potentials to its terminals. However, many features of the axon and axon terminals, especially at inhibitory synapses, remain unknown. By directly recording from the axon and terminal of a cultured cerebellar Purkinje cell (PC), we demonstrate that low membrane excitabil...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.02.013

    authors: Kawaguchi SY,Sakaba T

    更新日期:2015-03-18 00:00:00

  • Curbing the excesses of youth: molecular insights into axonal pruning.

    abstract::The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s0896-6273(03)00364-7

    authors: Kantor DB,Kolodkin AL

    更新日期:2003-06-19 00:00:00

  • A dorsal elaboration in the spinal cord.

    abstract::Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s0896-6273(02)00710-9

    authors: Matise M

    更新日期:2002-05-16 00:00:00

  • 5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in Aplysia sensory neurons.

    abstract::Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(89)90046-9

    authors: Barzilai A,Kennedy TE,Sweatt JD,Kandel ER

    更新日期:1989-06-01 00:00:00

  • The magnificent compromise: cortical field evolution in mammals.

    abstract::The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2007.10.002

    authors: Krubitzer L

    更新日期:2007-10-25 00:00:00

  • Multiple photopigments entrain the Mammalian circadian oscillator.

    abstract::Circadian rhythms are entrained to the natural day:night cycle. Melanopsin expressed in retinal ganglion cells partially accounts for circadian photoentrainment. Dkhissi-Benyahya et al. demonstrate that medium wavelength opsin (MW-opsin) also plays an important role in the process. Furthermore, they develop a model ex...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.neuron.2007.02.017

    authors: Panda S

    更新日期:2007-03-01 00:00:00

  • Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping.

    abstract::We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.12.021

    authors: Sgaier SK,Millet S,Villanueva MP,Berenshteyn F,Song C,Joyner AL

    更新日期:2005-01-06 00:00:00

  • Functional expression of sodium channel mutations identified in families with periodic paralysis.

    abstract::Two mutations in the sodium channel alpha subunit that have been implicated as the cause of periodic paralysis were studied by functional expression in a mammalian cell line. Both mutations disrupted inactivation without affecting the time course of the onset of the sodium current or the single-channel conductance. Th...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90321-h

    authors: Cannon SC,Strittmatter SM

    更新日期:1993-02-01 00:00:00

  • Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate.

    abstract::Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2004.09.006

    authors: Buckner RL

    更新日期:2004-09-30 00:00:00

  • Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

    abstract::Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following sensory deprivation in a subset of inhibitory (layer 2/3 GAD65-positive) and excitatory (layer 5 ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.09.052

    authors: Barnes SJ,Franzoni E,Jacobsen RI,Erdelyi F,Szabo G,Clopath C,Keller GB,Keck T

    更新日期:2017-11-15 00:00:00