Abstract：
:The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex behaviors that are associated with the painful conditions caused by peripheral nerve damage. Older Prx-/- animals display extensive peripheral demyelination and a severe clinical phenotype with mechanical allodynia and thermal hyperalgesia, which can be reversed by intrathecal administration of a selective NMDA receptor antagonist We conclude that the periaxins play an essential role in stabilizing the Schwann cell-axon unit and that the periaxin-deficient mouse will be an important model for studying neuropathic pain in late onset demyelinating disease.
journal_name
Neuronjournal_title
Neuronauthors
Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJdoi
10.1016/s0896-6273(00)81184-8subject
Has Abstractpub_date
2000-05-01 00:00:00pages
523-31issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)81184-8journal_volume
26pub_type
杂志文章相关文献
NEURON文献大全abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.03.025
更新日期：2011-06-09 00:00:00
abstract：:Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.037
更新日期：2014-09-03 00:00:00
abstract：:We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate dif...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.07.002
更新日期：2007-07-19 00:00:00
abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.03.017
更新日期：2016-05-04 00:00:00
abstract：:The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90290-t
更新日期：1992-02-01 00:00:00
abstract：:Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90182-5
更新日期：1995-10-01 00:00:00
abstract：:GABARAP recognizes and binds the gamma2 subunit of the GABA(A) receptor, interacts with microtubules and the N-ethyl maleimide sensitive factor, and is proposed to function in GABA(A) receptor trafficking and postsynaptic localization. We have determined the crystal structure of human GABARAP at 1.6 A resolution. The ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00558-x
更新日期：2002-01-03 00:00:00
abstract：:Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2016.02.042
更新日期：2016-03-16 00:00:00
abstract：UNLABELLED:Developmental dyslexia is a reading disorder, yet deficits also manifest in the magnocellular-dominated dorsal visual system. Uncertainty about whether visual deficits are causal or consequential to reading disability encumbers accurate identification and appropriate treatment of this common learning disabil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.002
更新日期：2013-07-10 00:00:00
abstract：:Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90046-9
更新日期：1989-06-01 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.05.005
更新日期：2016-06-15 00:00:00
abstract：:Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the recepto...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.04.024
更新日期：2011-06-23 00:00:00
abstract：:Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.009
更新日期：2014-05-07 00:00:00
abstract：:The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80965-4
更新日期：1997-10-01 00:00:00
abstract：:Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/close...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.09.023
更新日期：2007-10-04 00:00:00
abstract：:Experience-dependent plasticity in the adult brain has clinical potential for functional rehabilitation following central and peripheral nerve injuries. Here, plasticity induced by unilateral infraorbital (IO) nerve resection in 4-week-old rats was mapped using MRI and synaptic mechanisms were elucidated by slice elec...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.04.024
更新日期：2012-05-24 00:00:00
abstract：:This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00481-0
更新日期：2001-11-08 00:00:00
abstract：:After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90109-2
更新日期：1988-09-01 00:00:00
abstract：:Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90312-f
更新日期：1993-02-01 00:00:00
abstract：:The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90062-0
更新日期：1994-11-01 00:00:00
abstract：:Recent reports have overturned a series of dogmas that have been well entrenched in the neuroscience literature concerning NMDA-type glutamate receptors (NMDARs). The new data show that NMDARs exist on the myelin sheath formed by oligodendrocytes, that an uncompetitive NMDAR antagonist has successfully passed human cl...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.03.026
更新日期：2006-04-06 00:00:00
abstract：:Olfactory receptor neurons (ORNs) do not express the typical neuronal intermediate filament proteins (IFPs), the neurofilament triplet proteins. Immunocytochemical evidence shows that ORNs coexpress vimentin and peripherin but distribute them differently. Specifically, ORNs contain vimentin in dendrites, cell bodies, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90300-o
更新日期：1991-09-01 00:00:00
abstract：:The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90263-5
更新日期：1995-06-01 00:00:00
abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90338-g
更新日期：1990-12-01 00:00:00
abstract：:The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.04.019
更新日期：2006-05-18 00:00:00
abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.04.002
更新日期：2020-07-08 00:00:00
abstract：:From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00278-1
更新日期：2001-04-01 00:00:00
abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.04.015
更新日期：2018-06-06 00:00:00
abstract：:Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.045
更新日期：2020-01-08 00:00:00
abstract：:Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.08.012
更新日期：2011-09-08 00:00:00
