Abstract:
:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Carrier DmSLC22A, a member of the organic cation transporter family, enhances olfactory memory expression, while overexpression inhibits it. The protein localizes to the dendrites of the MBn, surrounding the presynaptic terminals of cholinergic afferent fibers from projection neurons (Pn). Cell-based expression assays show that this plasma membrane protein transports cholinergic compounds with the highest affinity among several in vitro substrates. Feeding flies choline or inhibiting acetylcholinesterase in Pn enhances memory, an effect blocked by overexpression of the transporter in the MBn. The data argue that DmSLC22A is a memory suppressor protein that limits memory formation by helping to terminate cholinergic neurotransmission at the Pn:MBn synapse.
journal_name
Neuronjournal_title
Neuronauthors
Gai Y,Liu Z,Cervantes-Sandoval I,Davis RLdoi
10.1016/j.neuron.2016.03.017subject
Has Abstractpub_date
2016-05-04 00:00:00pages
581-95issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30006-Xjournal_volume
90pub_type
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