Abstract:
:Neuroligins (NLs) are critical for synapse formation and function. NL3 R451C is an autism-associated mutation. NL3 R451C knockin (KI) mice exhibit autistic behavioral abnormalities, including social novelty deficits. However, neither the brain regions involved in social novelty nor the underlying mechanisms are clearly understood. Here, we found decreased excitability of fast-spiking interneurons and dysfunction of gamma oscillation in the medial prefrontal cortex (mPFC), which contributed to the social novelty deficit in the KI mice. Neuronal firing rates and phase-coding abnormalities were also detected in the KI mice during social interactions. Interestingly, optogenetic stimulation of parvalbumin interneurons in the mPFC at 40 Hz nested at 8 Hz positively modulated the social behaviors of mice and rescued the social novelty deficit in the KI mice. Our findings suggest that gamma oscillation dysfunction in the mPFC leads to social deficits in autism, and manipulating mPFC PV interneurons may reverse the deficits in adulthood.
journal_name
Neuronjournal_title
Neuronauthors
Cao W,Lin S,Xia QQ,Du YL,Yang Q,Zhang MY,Lu YQ,Xu J,Duan SM,Xia J,Feng G,Xu J,Luo JHdoi
10.1016/j.neuron.2018.02.001subject
Has Abstractpub_date
2018-03-21 00:00:00pages
1253-1260.e7issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30100-4journal_volume
97pub_type
杂志文章相关文献
NEURON文献大全abstract::Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.12.022
更新日期:2018-01-17 00:00:00
abstract::Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.10.004
更新日期:2015-11-18 00:00:00
abstract::Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.10.007
更新日期:2010-10-21 00:00:00
abstract::The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.021
更新日期:2005-08-18 00:00:00
abstract::Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.037
更新日期:2013-09-18 00:00:00
abstract::Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.11.024
更新日期:2005-12-08 00:00:00
abstract::To examine the distribution of synaptic vesicle antigens during development of the cerebral cortex, antibodies against synapsin I and p65 were used on sections of cat cerebral cortex between E40 and adulthood. In the adult, the layers of the cerebral cortex are immunoreactive for each of these antigens, while the whit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90078-5
更新日期:1988-06-01 00:00:00
abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.014
更新日期:2019-04-17 00:00:00
abstract::The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.06.002
更新日期:2010-07-15 00:00:00
abstract::Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spin...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00748-1
更新日期:2002-07-03 00:00:00
abstract::In this issue of Neuron, Wang et al. demonstrate that both cell-intrinsic and -extrinsic factors restrict the myelination of newly regenerated axons. Pharmalogical targeting of GPR17 signaling in oligodendrocyte precursor cells (OPCs) and microglial inhibition of oligodendrocyte maturation together promote robust myel...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.10.033
更新日期:2020-12-09 00:00:00
abstract::We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.07.018
更新日期:2010-08-12 00:00:00
abstract::In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80940-x
更新日期:1997-08-01 00:00:00
abstract::Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmis...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2007.05.009
更新日期:2007-05-24 00:00:00
abstract::Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00038-8
更新日期:2004-02-05 00:00:00
abstract::The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00672-4
更新日期:2002-05-16 00:00:00
abstract::Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.025
更新日期:2018-11-21 00:00:00
abstract::We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90058-n
更新日期:1990-03-01 00:00:00
abstract::The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.06.002
更新日期:2005-06-16 00:00:00
abstract::A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(02)00943-1
更新日期:2002-09-26 00:00:00
abstract::The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.02.028
更新日期:2005-04-07 00:00:00
abstract::Our perception of fine visual detail relies on small receptive fields at early stages of visual processing. However, small receptive fields tend to confound the orientation and velocity of moving edges, leading to ambiguous or inaccurate motion measurements (the aperture problem). Thus, it is often assumed that neuron...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00439-2
更新日期:2003-08-14 00:00:00
abstract::We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH mice expressed hGH in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90279-m
更新日期:1992-03-01 00:00:00
abstract::Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80739-4
更新日期:1999-04-01 00:00:00
abstract::Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.01.046
更新日期:2016-03-16 00:00:00
abstract::Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.024
更新日期:2014-12-03 00:00:00
abstract::We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00721-3
更新日期:2002-05-30 00:00:00
abstract::In this issue of Neuron, Stepanyants et al. embark on quantitative analyses of the axonal and dendritic arbors of cortical neurons. They test whether the paths taken by axons actually bring them closer to their true synaptic partners than they would have gotten by chance encounters based on the same axon trajectories....
journal_title:Neuron
pub_type: 评论
doi:10.1016/j.neuron.2004.07.006
更新日期:2004-07-22 00:00:00
abstract::In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.029
更新日期:2010-06-10 00:00:00
abstract::We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80195-6
更新日期:1996-10-01 00:00:00