MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion.

abstract：:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...

journal_title：Neuron

authors： Gonzalez-Castillo J,Bandettini PA

更新日期：2015-06-17 00:00:00

abstract：:Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and Ts1Cje mouse models of DS to show that the increased dose of the amyloid precursor protein gene, App, acts to markedly decrease NGF retrograde transp...

journal_title：Neuron

authors： Salehi A,Delcroix JD,Belichenko PV,Zhan K,Wu C,Valletta JS,Takimoto-Kimura R,Kleschevnikov AM,Sambamurti K,Chung PP,Xia W,Villar A,Campbell WA,Kulnane LS,Nixon RA,Lamb BT,Epstein CJ,Stokin GB,Goldstein LS,Mobley WC

更新日期：2006-07-06 00:00:00

abstract：:Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated wit...

journal_title：Neuron

authors： Coulthard EJ,Nachev P,Husain M

更新日期：2008-04-10 00:00:00

abstract：:Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse chan...

journal_title：Neuron

authors： Wang GX,Smith SJ,Mourrain P

更新日期：2014-12-17 00:00:00

abstract：:A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...

journal_title：Neuron

authors： Kuo SP,Trussell LO

更新日期：2009-09-10 00:00:00

abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...

journal_title：Neuron

authors： Kim J,Basak JM,Holtzman DM

更新日期：2009-08-13 00:00:00

abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...

journal_title：Neuron

authors： Brunwasser SJ,Hengen KB

更新日期：2020-02-19 00:00:00

abstract：:Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of heat-evoked single channel currents in excised memb...

journal_title：Neuron

authors： Tominaga M,Caterina MJ,Malmberg AB,Rosen TA,Gilbert H,Skinner K,Raumann BE,Basbaum AI,Julius D

更新日期：1998-09-01 00:00:00

abstract：:Biochemical studies suggest that syntaxin 1A participates in multiple protein-protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to eliminate specific syntaxin binding interactions and demonstrate that Drosophi...

journal_title：Neuron

authors： Wu MN,Fergestad T,Lloyd TE,He Y,Broadie K,Bellen HJ

更新日期：1999-07-01 00:00:00

abstract：:The fields of neuroscience and artificial intelligence (AI) have a long and intertwined history. In more recent times, however, communication and collaboration between the two fields has become less commonplace. In this article, we argue that better understanding biological brains could play a vital role in building i...

journal_title：Neuron

authors： Hassabis D,Kumaran D,Summerfield C,Botvinick M

更新日期：2017-07-19 00:00:00

abstract：:Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...

journal_title：Neuron

authors： Ballivet M,Nef P,Couturier S,Rungger D,Bader CR,Bertrand D,Cooper E

更新日期：1988-11-01 00:00:00

abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...

journal_title：Neuron

authors： Patneau DK,Wright PW,Winters C,Mayer ML,Gallo V

更新日期：1994-02-01 00:00:00

abstract：:The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a process known as heat hypera...

journal_title：Neuron

authors： Zhang X,Li L,McNaughton PA

更新日期：2008-08-14 00:00:00

abstract：:To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...

journal_title：Neuron

authors： Iwatsubo T,Odaka A,Suzuki N,Mizusawa H,Nukina N,Ihara Y

更新日期：1994-07-01 00:00:00

abstract：:Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing a...

journal_title：Neuron

authors： Schultz W

更新日期：2002-10-10 00:00:00

abstract：:Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...

journal_title：Neuron

authors： Goulding M

更新日期：2004-09-02 00:00:00

abstract：:Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasin...

journal_title：Neuron

authors： McNeil GP,Zhang X,Genova G,Jackson FR

更新日期：1998-02-01 00:00:00

abstract：:Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...

journal_title：Neuron

authors： Hasan MT,Althammer F,Silva da Gouveia M,Goyon S,Eliava M,Lefevre A,Kerspern D,Schimmer J,Raftogianni A,Wahis J,Knobloch-Bollmann HS,Tang Y,Liu X,Jain A,Chavant V,Goumon Y,Weislogel JM,Hurlemann R,Herpertz SC,Pitzer

更新日期：2019-07-03 00:00:00

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...

journal_title：Neuron

authors： Kreitzer AC,Regehr WG

更新日期：2001-03-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...

journal_title：Neuron

authors： Banghart MR,Neufeld SQ,Wong NC,Sabatini BL

更新日期：2015-12-16 00:00:00

abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...

journal_title：Neuron

authors： Udeochu J,Sayed FA,Gan L

更新日期：2018-03-07 00:00:00

abstract：:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...

journal_title：Neuron

authors： Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

更新日期：2005-12-08 00:00:00

abstract：:Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca(2+) imaging in cells expressing the gene...

journal_title：Neuron

authors： Gabriel JP,Trivedi CA,Maurer CM,Ryu S,Bollmann JH

更新日期：2012-12-20 00:00:00

abstract：:Terminal Schwann cells overlying the neuromuscular junction sprout elaborate processes upon muscle denervation. We show here that motor axons use these processes as guides/substrates during regeneration; in so doing, they escape the confines of endplates and grow between endplates to generate polyneuronal innervation....

journal_title：Neuron

authors： Son YJ,Thompson WJ

更新日期：1995-01-01 00:00:00

abstract：:We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

journal_title：Neuron

authors： Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

更新日期：1990-08-01 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...

journal_title：Neuron

authors： Bennett C,Arroyo S,Hestrin S

更新日期：2013-10-16 00:00:00

abstract：:Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent l...

journal_title：Neuron

authors： Woolf CJ

更新日期：2003-04-24 00:00:00