Cadherin regulates dendritic spine morphogenesis.

abstract：:Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explain local rhythmic behaviors. In C. elegans, we report that proprioception within the motor circuit is responsible for propag...

journal_title：Neuron

authors： Wen Q,Po MD,Hulme E,Chen S,Liu X,Kwok SW,Gershow M,Leifer AM,Butler V,Fang-Yen C,Kawano T,Schafer WR,Whitesides G,Wyart M,Chklovskii DB,Zhen M,Samuel AD

更新日期：2012-11-21 00:00:00

abstract：:In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents. ...

journal_title：Neuron

authors： Hill RZ,Bautista DM

更新日期：2019-01-16 00:00:00

abstract：:mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...

journal_title：Neuron

authors： Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RA

更新日期：1991-08-01 00:00:00

abstract：:Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection...

journal_title：Neuron

authors： Lak A,Okun M,Moss MM,Gurnani H,Farrell K,Wells MJ,Reddy CB,Kepecs A,Harris KD,Carandini M

更新日期：2020-02-19 00:00:00

abstract：:Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...

journal_title：Neuron

authors： Tanigaki K,Nogaki F,Takahashi J,Tashiro K,Kurooka H,Honjo T

更新日期：2001-01-01 00:00:00

abstract：:In this issue of Neuron, Moehle et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine in an output nucleus of the basal ganglia. They provide intracellular, anatomical, and network-level mechanisms for this cholinergic-dopaminergic interplay. ...

journal_title：Neuron

authors： Kaganovsky K,Ding JB

更新日期：2017-12-20 00:00:00

abstract：:Although animal studies provided significant insights in understanding the neural basis of learning and adaptation, they often cannot dissociate between different learning mechanisms due to the lack of verbal communication. To overcome this limitation, we examined the mechanisms of learning and its limits in a human i...

journal_title：Neuron

authors： Sakellaridi S,Christopoulos VN,Aflalo T,Pejsa KW,Rosario ER,Ouellette D,Pouratian N,Andersen RA

更新日期：2019-05-08 00:00:00

abstract：:The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from...

journal_title：Neuron

authors： Koleske AJ,Gifford AM,Scott ML,Nee M,Bronson RT,Miczek KA,Baltimore D

更新日期：1998-12-01 00:00:00

abstract：:We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...

journal_title：Neuron

authors： Ip NY,McClain J,Barrezueta NX,Aldrich TH,Pan L,Li Y,Wiegand SJ,Friedman B,Davis S,Yancopoulos GD

更新日期：1993-01-01 00:00:00

abstract：:Flies exhibit a repertoire of aerial acrobatics unmatched in robustness and aerodynamic sophistication. The exquisite control of this complex behavior emerges from encoding intricate patterns of optic flow, and the translation of these visual signals into the mechanical language of the motor system. Recent advances in...

journal_title：Neuron

authors： Frye MA,Dickinson MH

更新日期：2001-11-08 00:00:00

abstract：:The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...

journal_title：Neuron

authors： Shackleford GM,Willert K,Wang J,Varmus HE

更新日期：1993-11-01 00:00:00

abstract：:The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...

journal_title：Neuron

authors： Hudspeth AJ

更新日期：2008-08-28 00:00:00

abstract：:Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a c...

journal_title：Neuron

authors： Wada E,Way J,Shapira H,Kusano K,Lebacq-Verheyden AM,Coy D,Jensen R,Battery J

更新日期：1991-03-01 00:00:00

abstract：:In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...

journal_title：Neuron

authors： Rowland DC,Moser MB

更新日期：2013-06-19 00:00:00

abstract：:Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localizati...

journal_title：Neuron

authors： Porter J,Anand T,Johnson B,Khan RM,Sobel N

更新日期：2005-08-18 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...

journal_title：Neuron

authors： Ninan I,Arancio O

更新日期：2004-04-08 00:00:00

abstract：:The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endoc...

journal_title：Neuron

authors： Hosoi N,Holt M,Sakaba T

更新日期：2009-07-30 00:00:00

abstract：:The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid receptors. We show that ABHD6 inhibition decreases pentylenetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic sei...

journal_title：Neuron

authors： Naydenov AV,Horne EA,Cheah CS,Swinney K,Hsu KL,Cao JK,Marrs W,Blankman JL,Tu S,Cherry AE,Fung S,Wen A,Li W,Saporito MS,Selley DE,Cravatt BF,Oakley JC,Stella N

更新日期：2014-07-16 00:00:00

abstract：:Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...

journal_title：Neuron

authors： Franks KM,Isaacson JS

更新日期：2006-02-02 00:00:00

abstract：:In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...

journal_title：Neuron

authors： Maricich SM,Gilmore EC,Herrup K

更新日期：2001-08-02 00:00:00

abstract：:Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...

journal_title：Neuron

authors： Akabas MH,Kaufmann C,Archdeacon P,Karlin A

更新日期：1994-10-01 00:00:00

abstract：UNLABELLED:Developmental dyslexia is a reading disorder, yet deficits also manifest in the magnocellular-dominated dorsal visual system. Uncertainty about whether visual deficits are causal or consequential to reading disability encumbers accurate identification and appropriate treatment of this common learning disabil...

journal_title：Neuron

authors： Olulade OA,Napoliello EM,Eden GF

更新日期：2013-07-10 00:00:00

abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...

journal_title：Neuron

authors： Pixley SK

更新日期：1992-06-01 00:00:00

abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...

journal_title：Neuron

authors： Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

更新日期：2006-09-21 00:00:00

abstract：:The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the ne...

journal_title：Neuron

authors： Medalla M,Barbas H

更新日期：2009-02-26 00:00:00

abstract：:K+ channels contain two main functional domains, an ion-selective pore and a sensor that determines whether the cytoplasmic pore gate is open or closed. In this issue of Neuron, Niu et al. provide compelling evidence that the link between sensor and gate is a remarkably simple mechanical spring. ...

journal_title：Neuron

authors： Papazian DM

更新日期：2004-06-10 00:00:00

abstract：:Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...

journal_title：Neuron

authors： Sommer L,Shah N,Rao M,Anderson DJ

更新日期：1995-12-01 00:00:00

abstract：:The mechanism of kainate receptor targeting and clustering is still unresolved. Here, we demonstrate that members of the SAP90/PSD-95 family colocalize and associate with kainate receptors. SAP90 and SAP102 coimmunoprecipitate with both KA2 and GluR6, but only SAP97 coimmunoprecipitates with GluR6. Similar to NMDA rec...

journal_title：Neuron

authors： Garcia EP,Mehta S,Blair LA,Wells DG,Shang J,Fukushima T,Fallon JR,Garner CC,Marshall J

更新日期：1998-10-01 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...

journal_title：Neuron

authors： Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

更新日期：2010-12-09 00:00:00