Abstract:
:In this issue of Neuron, Moehle et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine in an output nucleus of the basal ganglia. They provide intracellular, anatomical, and network-level mechanisms for this cholinergic-dopaminergic interplay.
journal_name
Neuronjournal_title
Neuronauthors
Kaganovsky K,Ding JBdoi
10.1016/j.neuron.2017.12.014subject
Has Abstractpub_date
2017-12-20 00:00:00pages
1208-1210issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(17)31137-6journal_volume
96pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.04.029
更新日期:2019-07-03 00:00:00
abstract::Theta oscillations reflect rhythmic inputs that continuously converge to the hippocampus during exploratory and memory-guided behavior. The theta-nested operations that organize hippocampal spiking could either occur regularly from one cycle to the next or be tuned on a cycle-by-cycle basis. To resolve this, we identi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.031
更新日期:2018-11-21 00:00:00
abstract::The brain basis of language, music, and emotion can be studied from the perspective of the psychological and cognitive sciences. Does this approach link to concerns of the humanities meaningfully? We outline prospects of developing a genuine neurohumanities research program. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.10.021
更新日期:2020-11-25 00:00:00
abstract::Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.05.016
更新日期:2007-06-07 00:00:00
abstract::Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90211-2
更新日期:1995-04-01 00:00:00
abstract::Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, C...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.09.022
更新日期:2014-10-22 00:00:00
abstract::We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80195-6
更新日期:1996-10-01 00:00:00
abstract::To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00048-0
更新日期:2004-02-19 00:00:00
abstract::Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.03.021
更新日期:2018-04-18 00:00:00
abstract::S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways,...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.05.005
更新日期:2013-05-22 00:00:00
abstract::Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80282-2
更新日期:1996-07-01 00:00:00
abstract::Chen et al present data describing millisecond interactions in a human hyperdirect pathway that connects the inferior frontal gyrus and the subthalamic nucleus. They study this circuit during a stop-signal task in the context of inhibitory control. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.04.017
更新日期:2020-05-20 00:00:00
abstract::Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.011
更新日期:2016-09-21 00:00:00
abstract::Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.03.010
更新日期:2007-04-05 00:00:00
abstract::Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol ph...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00456-1
更新日期:2001-10-11 00:00:00
abstract::In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.029
更新日期:2010-06-10 00:00:00
abstract::Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81113-7
更新日期:1999-11-01 00:00:00
abstract::Spine morphology is regulated by intracellular signals, like PKC, that affect cytoskeletal and membrane dynamics. We investigated the role of MARCKS (myristoylated, alanine-rich C-kinase substrate) in dendrites of 3-week-old hippocampal cultures. MARCKS associates with membranes via the combined action of myristoylati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.08.027
更新日期:2005-10-06 00:00:00
abstract::The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.052
更新日期:2015-10-21 00:00:00
abstract::Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00573-1
更新日期:2002-01-31 00:00:00
abstract::Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.024
更新日期:2014-12-03 00:00:00
abstract::Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.06.030
更新日期:2006-08-03 00:00:00
abstract::How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.033
更新日期:2019-08-21 00:00:00
abstract::Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00179-9
更新日期:2001-01-01 00:00:00
abstract::The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00236-7
更新日期:2001-03-01 00:00:00
abstract::Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.05.030
更新日期:2012-08-09 00:00:00
abstract::During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81034-x
更新日期:1999-12-01 00:00:00
abstract::Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.11.018
更新日期:2020-02-19 00:00:00
abstract::In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.001
更新日期:2010-03-25 00:00:00
abstract::Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.01.039
更新日期:2019-03-06 00:00:00