Abstract：
:Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic factors, it remains difficult to design rational treatments. In this review, we highlight the value of understanding neural circuit function both as an intermediate level of explanatory description that links gene to behavior and as a pathway for developing rational diagnostics and therapeutics for behavioral disorders. As neural circuits perform hierarchically organized computational functions and give rise to network-level processes (e.g., macroscopic rhythms and goal-directed or homeostatic behaviors), correlated network-level deficits may indicate perturbation of a specific circuit. Therefore, identifying such correlated deficits or a circuit endophenotype would provide a mechanistic point of entry, enhancing both diagnosis and treatment of a given behavioral disorder. We focus on a circuit endophenotype of the thalamic reticular nucleus (TRN) and how its impairment in neurodevelopmental disorders gives rise to a correlated set of readouts across sleep and attention. Because TRN neurons express several disorder-relevant genes identified through genome-wide association studies, exploring the consequences of different TRN disruptions may be of broad translational significance.
journal_name
Neuronjournal_title
Neuronauthors
Krol A,Wimmer RD,Halassa MM,Feng Gdoi
10.1016/j.neuron.2018.03.021subject
Has Abstractpub_date
2018-04-18 00:00:00pages
282-295issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30198-3journal_volume
98pub_type
杂志文章,评审相关文献
NEURON文献大全abstract：:In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2016.07.008
更新日期：2016-07-20 00:00:00
abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2019.01.039
更新日期：2019-03-06 00:00:00
abstract：:Live imaging studies in mice show that adult-born oligodendrocytes and myelin are remarkably stable. Neural activity enhances oligodendrocyte integration, arguing that internode addition rather than alteration represents the mechanism for any experience-dependent cortical myelination changes that might underpin learni...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.05.005
更新日期：2018-05-16 00:00:00
abstract：:As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00370-2
更新日期：2003-07-03 00:00:00
abstract：:We have cloned the rat gene encoding peripherin, a neuronal-specific intermediate filament protein that is NGF-regulated. Determination of the complete sequence, including 821 nucleotides of the 5'-flanking region, allows us to make conclusions about the evolutionary origin of the peripherin gene, its homology with ot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90228-6
更新日期：1989-01-01 00:00:00
abstract：:Neuroscience is an exciting and vibrant field, but building an academic career is not always easy. What are critical success indicators? Which tools help talented young neuroscientists conquer the challenges? In this NeuroView, we discuss instruments and steps that can help people progress through the ranks. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.04.002
更新日期：2015-05-06 00:00:00
abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.001
更新日期：2019-02-20 00:00:00
abstract：:LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(02)00759-6
更新日期：2002-07-03 00:00:00
abstract：:Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.07.034
更新日期：2020-10-28 00:00:00
abstract：:Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81174-5
更新日期：2000-05-01 00:00:00
abstract：:Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underl...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2005.02.005
更新日期：2005-03-03 00:00:00
abstract：:In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.08.035
更新日期：2014-10-01 00:00:00
abstract：:The present study utilized event-related fMRI to address the role of the human perirhinal cortex (PRC), and its interactions with the hippocampus, in memory consolidation. Participants encoded object-based and scene-based associations and then restudied them either after a "long" or "short" delay during which consolid...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.07.013
更新日期：2013-09-18 00:00:00
abstract：:An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00201-0
更新日期：2003-04-10 00:00:00
abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.09.025
更新日期：2018-11-21 00:00:00
abstract：VIDEO ABSTRACT:Why do people often choose to cooperate when they can better serve their interests by acting selfishly? One potential mechanism is that the anticipation of guilt can motivate cooperative behavior. We utilize a formal model of this process in conjunction with fMRI to identify brain regions that mediate co...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.02.056
更新日期：2011-05-12 00:00:00
abstract：:The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endoc...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.06.010
更新日期：2009-07-30 00:00:00
abstract：:The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00368-4
更新日期：2003-07-03 00:00:00
abstract：:We examined the contribution of the amygdala to value signals within orbital prefrontal cortex (OFC) and medial prefrontal cortex (MFC). On each trial, monkeys chose between two stimuli that were associated with different quantities of reward. In intact monkeys, as expected, neurons in both OFC and MFC signaled the re...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.09.036
更新日期：2013-12-18 00:00:00
abstract：:Motoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific kinase (MuSK), a major component of the agrin receptor. Like MuSK, Tid1 coloca...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.09.025
更新日期：2008-11-26 00:00:00
abstract：:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.02.017
更新日期：2011-02-24 00:00:00
abstract：:Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these resp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.05.009
更新日期：2018-06-06 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) are membrane spanning proteins with intrinsic kinase activity. Although these receptors are known to be involved in proliferation and differentiation of cells, their roles in regulating central synaptic transmission are largely unknown. In CA1 pyramidal neurons, activation of D2 class ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00859-0
更新日期：2002-09-12 00:00:00
abstract：:Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.04.003
更新日期：2017-05-03 00:00:00
abstract：:An axon is thought to faithfully conduct action potentials to its terminals. However, many features of the axon and axon terminals, especially at inhibitory synapses, remain unknown. By directly recording from the axon and terminal of a cultured cerebellar Purkinje cell (PC), we demonstrate that low membrane excitabil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.02.013
更新日期：2015-03-18 00:00:00
abstract：:Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.008
更新日期：2005-07-21 00:00:00
abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2017.02.047
更新日期：2017-05-03 00:00:00
abstract：:The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant cir...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.03.041
更新日期：2006-05-04 00:00:00
abstract：:The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80270-6
更新日期：1997-02-01 00:00:00
abstract：:Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90312-f
更新日期：1993-02-01 00:00:00
