Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value.

Abstract:

:Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection with reinforcement learning. In the model, the predicted value of the chosen option is the product of sensory confidence and learned value. We found precise correlates of this variable in the pre-outcome activity of midbrain dopamine neurons and of medial prefrontal cortical neurons. However, only the latter played a causal role: inactivating medial prefrontal cortex before outcome strengthened learning from the outcome. Dopamine neurons played a causal role only after outcome, when they encoded reward prediction errors graded by confidence, influencing subsequent choices. These results reveal neural signals that combine reward value with sensory confidence and guide subsequent learning.

journal_name

Neuron

journal_title

Neuron

authors

Lak A,Okun M,Moss MM,Gurnani H,Farrell K,Wells MJ,Reddy CB,Kepecs A,Harris KD,Carandini M

doi

10.1016/j.neuron.2019.11.018

subject

Has Abstract

pub_date

2020-02-19 00:00:00

pages

700-711.e6

issue

4

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(19)30982-1

journal_volume

105

pub_type

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