Light-induced plasticity of synaptic AMPA receptor composition in retinal ganglion cells.

Abstract:

:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapted mouse retina, we report a retina-specific form of AMPAR plasticity. Both chemical and light activation of NMDARs caused the selective endocytosis of GluA2-containing, Ca(2+)-impermeable AMPARs on RGCs and replacement with GluA2-lacking, Ca(2+)-permeable AMPARs. The plasticity was expressed in ON but not OFF RGCs and was restricted solely to the ON responses in ON-OFF RGCs. Finally, the plasticity resulted in a shift in the light responsiveness of ON RGCs. Thus, physiologically relevant light stimuli can induce a change in synaptic receptor composition of ON RGCs, providing a mechanism by which the sensitivity of RGC responses may be modified under scotopic conditions.

journal_name

Neuron

journal_title

Neuron

authors

Jones RS,Carroll RC,Nawy S

doi

10.1016/j.neuron.2012.05.030

subject

Has Abstract

pub_date

2012-08-09 00:00:00

pages

467-78

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(12)00526-0

journal_volume

75

pub_type

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